Hey low C3 and 4 is much more relevant than my raised ones L. I think I have had spells of Sarcoidosis when the P Sjogrens started - years of dry coughing fits lasting for hours and comimg on randomly with no explanation apart from probable reflux. I'm almost jealous of myself after five years of feeling tied to a disease I never fully related to.

I will post this on the main forum for others but I thought this Arthritis Research diagnostic tool was particularly interesting. I've had years of wondering what was causing my high ESR and CRP when I had very little joint pain. Then today I read this I learn something everyday. Apparently most people with PSJS have a very high ESR often but, unlike with RA, this doesn't correspond with the level of disease activity. At last I understand why my levels are often so high despite no swollen joints.

"People with Sjögren’s syndrome often have very high ESR levels regardless of whether they feel well or ill. In Sjögren’s syndrome, the ESR or other measurements of inflammation such as C-reactive protein (CRP) aren't very useful in assessing how active the condition is – unlike in lupus or rheumatoid arthritis."

http://www.arthritisresearchuk.org/a...diagnosis.aspx