I had a skin biopsy done in the spring. While I have had large fiber neuropathy confirmed since 2011 and sfn symptoms for a long time it was not confirmed.


Today I received the results from the biopsy.

left calf- normal value >4.4 my nerve fiber density 0.0

left lower thigh normal value >6.0 my nerve fiber density 3.8

left upper thigh normal value >7 my nerve fiber density 1.8


Abnormal nerve fiber density at all sites. This is consistent with a severe neuropathy affecting small nerve fibers.

On the plus side the morphology is normal on what is present & despite results worse than I expected I am holding on fairly well. I struggle at times with pain, fatigue often, but I am going to do a sleep study to see if apnea plays in at all on that front.

It is good to have the hard numbers, but I am still startled a bit by them, especially the calf one.

Great to read your posts !

I understand the 'startled' at the 0.0 results.....my 2 biopsy's right above my ankle were 0.0 and 0.06.

Glad to hear you are doing ok.....the fatigue is a bummer for sure.

Debi from Georgia