Just wanted to share a quick update. It's now been three years since I began to experience twitching and cramping symptoms, which morphed into pain, particularly on the bottoms of my feet. After 6 months, my symptoms stabilized and have not gotten any worse. Despite ongoing visits to the Neurologist, I have never gotten a diagnosis - but it would certainly appear to be some type of SFN based on the symptoms.

Over the past several months, I reduced my Gabapentin dosage from 1800 mg/day, down to almost being completely off of it - but them the pain started to increase and some leg cramping returned as well. So, I increased back to 600 mg/day and things are much better. At least now I know what dosage I really need.

I'm also still taking multiple supplements, although slowly tapering off of some of them that are not specifically related to my A1298C MTHFR mutation.

Other than that, things are pretty normal for me. I still have some pain in the feet, but I've kind of gotten used to it, and I'm able to do most of the things I did before this disease hit me. I'm thankful every day that things have not gotten any worse, and I pray every day that it will stay that way.

Wishing everyone here improved health