Here's a potential example of why your supplementation is not working anymore. It has to do with being overloaded with methyl forms of B12 and folate. It's characterized as "the honeymoon". You feel great at first but a week or two out and it's back to your old symptoms. MTHFR site has a ton of info on B12/folate but is not always the easiest to find what you're looking for.

If this is the case, more is not better. Stopping it for a while and re-introducting them one at a time can provide you with some insights. And, maybe just take them every two or three days versus daily. It can be a bit overwhelming to figure out.

http://mthfr.net/methylfolate-side-effects/2012/03/01/

Specific to your questions, we take a separate B12 on an empty stomach and then include a B complex with a full meal. We don't do this daily anymore. It's more to maintain levels vs restoring a deficiency.

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We're all different, and have to find our own way.

I'm just starting to explore vitamin B6 toxicity (as possible cause or contributor to 15 years of Peripheral Neuropathy), and it's another maze. No doctor even mentioned it for those 15 years, it's a known cause of PN, and recently I found my B6 levels are abnormally high. Hmm.

Though, that abnormal result, I've found, can itself be misleading--it could be due to damaged blood cells during the blood testing process, or it could be that my serum levels are HIGH but intracellular levels are LOW (which then leads to the question, why...). And if B6 toxicity is a factor, it's not that easy to solve.

In all this, be wary of simple answers.

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Sorry, I'm too new here to be allowed to post links (?!).

--one's B12 alone, completely separate from any other supplements, and at least two hours after food or one hour before.

The cobalamin molecule is the largest molecule our body uses as a nutrient on a regular basis; it is VERY easy to interfere with its absorption, especially if one has problems in that area to begin with. Even taking it with other B vitamins tends to set up a competition that the larger B12 molecule is likely to come out on the short end of.

I would try taking your B12, in whatever form you're taking it, completely separate and alone for a number of months and then compare.