Pirenzepine

NoMiS499 · 08-19-2019, 01:23 PM

Quote:

Originally Posted by mhw69

You should be looking for Oxytrol. It is a transdermal patch used for bladder spasms. I am trying it right now with interesting results. I have less numbness / improved sensation in numb area of feet, more skin wrinkling in water with my hands ( improvement in autonomic neuropathy), more tingling in neuropathic areas (maybe Tinel's sign for regenerating axons).

It is a bit of a mixed bag though because I still experience stinging pains and the electrical pains. However, I just read a paper that said that these pains occur with regenerating axons because of changes in the number of sodium channels. The issue appears that continuous neuropathic pain is an ongoing regeneration process that never succeeds in fully reinnervating the tissue. Ironically enough the people who just develop numbness without pain have a less healthy peripheral nervous system because no regeneration is going on. They just lose nerves and go totally numb. The people who have pain going on have regeneration happening but the regeneration is overwhelmed by the neuropathic disease process. Some researchers are trying out drugs to turn off the regeneration process to bring relief to people with pain where there is no hope for successful regeneration. Personally, I would be reluctant to use it.

I know it's only been a short time since this comment but do you still think the oxytrol transdermal patch is working for you?

mhw69 · 08-21-2019, 09:28 AM

Quote:

Originally Posted by NoMiS499

I know it's only been a short time since this comment but do you still think the oxytrol transdermal patch is working for you?

I do think that it is helping me but it is pretty subjective at this point. I feel like I am regaining sensation in my toes. I have had a definite change in the types of symptoms that I experience. I get more itching and tingling than I have had in the past and these can be signs of nerve regeneration (Tinel's sign). I also seem to get more skin wrinkling in water which is a good sign. The only way to figure out if this is happening is to look back retrospectively and see where you have been and where you are. Hit me up a few months from now and ask me again. I suspect that I will have a better answer then.

mhw69 · 08-23-2019, 09:53 AM

Quote:

Originally Posted by NoMiS499

I know it's only been a short time since this comment but do you still think the oxytrol transdermal patch is working for you?

Here is some of the research that I looked at for oxybutynin. I chose it because of this research and the fact that it is available over the counter (OTC).

Muscarinic Receptor Antagonist Improves Nerve Fiber Function in Subjects with Type 2 Diabetes and Peripheral Neuropathy | Diabetes

A 6�-YEAR-OLD WOMAN WITH SMALL FIBER PERIPHERAL NEUROPATHY RECOVERY ON OXYBUTYNIN - ProQuest

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. - PubMed - NCBI

Happytobehere · 08-23-2019, 03:36 PM

Does anyone know if Pirenzepine is on a schedule controlled list in the US? I'm asking because I've noticed an irregularity in the normal path my packages takes just before arriving (its almost to my front door) when using the tracking number I was given. I've never seen a package take this path before. I've googled every possible way I could such as "Is Pirenzepine a schedule controlled substance" with no results saying it is. Anyone know? Thanks in advance for any and all info.

nilram · 09-05-2019, 01:43 AM

Quote:

Originally Posted by Happytobehere

Does anyone know if Pirenzepine is on a schedule controlled list in the US? I'm asking because I've noticed an irregularity in the normal path my packages takes just before arriving (its almost to my front door) when using the tracking number I was given. I've never seen a package take this path before. I've googled every possible way I could such as "Is Pirenzepine a schedule controlled substance" with no results saying it is. Anyone know? Thanks in advance for any and all info.

Is it sent to you (I presume, in the US?) by a non-US pharmacy? It's not a DEA scheduled drug, but it's also not listed as approved by the FDA. (So it's not available from US pharmacies.) Almost all drugs approved for use in the US are listed in the "Orange Book" (Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations).

A listing of scheduled drugs can be found at Drug Scheduling. (Interesting that the list includes Lyrica/pregabilin, but not gabapentin, even though--I'm told--they act on the same exact receptor.) Pirenzepine is not on that list.

Happytobehere · 09-11-2019, 05:01 AM

Sorry this site won't let me post actual links yet but you can get the ideal of which site it is from this. ** and received Pirenzepine but still made my feet swell. So I guess I'm screwed with getting the use from this. unless the gel might work a little different.

mncyclist · 10-31-2019, 08:38 PM

I guess there are many of us interested in this. Just diagnosed with SFPN (small fiber peripheral neuropathy). Some toe, balls of feet numbness, slight burning and the shock thing.

I've ordered the 25mg pirenzepine tablets from an overseas pharmacy and will be trialing this shortly myself.

I'll keep you posted.

Note that a person on reddit did this too and good results. 25mg a day, slight stomach discomfort.

mncyclist · 11-01-2019, 08:16 PM

Quote:

Originally Posted by Happytobehere

Sorry this site won't let me post actual links yet but you can get the ideal of which site it is from this. ** and received Pirenzepine but still made my feet swell. So I guess I'm screwed with getting the use from this. unless the gel might work a little different.

Any thoughts on making your own topical med from your pirenzepine?

If you search reddit for pirenzepine you'll read another story of an SFN sufferer who reversed many of their symptoms.

mncyclist · 11-24-2019, 08:14 PM

Quote:

Originally Posted by mncyclist

Any thoughts on making your own topical med from your pirenzepine?

If you search reddit for pirenzepine you'll read another story of an SFN sufferer who reversed many of their symptoms.

Just posting an update. I've been on 100mg pirenzepine for about three weeks now. I'm not having any stomach issues and am tolerating it quite well.

Will report back again on neuropathy results.

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