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Old 02-24-2019, 02:04 PM   #1
Streetlegal
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Default Pirenzepine

Hi all,

Can any longer term members remember posts from a member who was self-trialing Pirenzepine for a short period of time?

I distinctly remember her(?) describing the ongoing sensations, but then she ended the trial.

Or am I mis-remembering?

Thank you!

Paul
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Old 03-03-2019, 06:45 PM   #2
liquidz1
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Originally Posted by Streetlegal View Post
Hi all,

Can any longer term members remember posts from a member who was self-trialing Pirenzepine for a short period of time?

I distinctly remember her(?) describing the ongoing sensations, but then she ended the trial.

Or am I mis-remembering?

Thank you!

Paul

Are you going to give it a try?seems to be a harmless drug other than stomach discomfort
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Old 03-03-2019, 11:25 PM   #3
kiwi33
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The results of this technical rodent model study look encouraging.

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy
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Old 03-04-2019, 10:08 PM   #4
Streetlegal
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"Are you going to give it a try?seems to be a harmless drug other than stomach discomfort"

I thought a bit about it, but I've heard that oral administration has proved an ineffective route. The focus of the trials is on topical administration because of this and because of safety issues. Of course, it's early very, very early days.

I also worry about potential side-effects (I actually have colitis, but have also heard of possible concerns regarding dementia, though haven't read anything to this fact).

I believe that research will be coming out in a few months regarding early trials of the topical lotion. It's a long-shot. But at least it is something.

Cheers
Paul
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Old 03-05-2019, 05:52 AM   #5
liquidz1
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Quote:
Originally Posted by Streetlegal View Post
"Are you going to give it a try?seems to be a harmless drug other than stomach discomfort"

I thought a bit about it, but I've heard that oral administration has proved an ineffective route. The focus of the trials is on topical administration because of this and because of safety issues. Of course, it's early very, very early days.

I also worry about potential side-effects (I actually have colitis, but have also heard of possible concerns regarding dementia, though haven't read anything to this fact).

I believe that research will be coming out in a few months regarding early trials of the topical lotion. It's a long-shot. But at least it is something.

Cheers
Paul
Topical cream was made to mainly combat the side effects from pills.The studies that i have read says that oral is effective as topical
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Old 03-05-2019, 09:25 AM   #6
Streetlegal
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Topical cream was made to mainly combat the side effects from pills.The studies that i have read says that oral is effective as topical
Hi Liqidz--are you sure about that? If you have any links to abstracts of articles I would be very interested.

Cheers
Paul
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Old 03-05-2019, 01:35 PM   #7
IPN1967
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Quote:
Originally Posted by Streetlegal View Post
"Are you going to give it a try?seems to be a harmless drug other than stomach discomfort"

I thought a bit about it, but I've heard that oral administration has proved an ineffective route. The focus of the trials is on topical administration because of this and because of safety issues. Of course, it's early very, very early days.

I also worry about potential side-effects (I actually have colitis, but have also heard of possible concerns regarding dementia, though haven't read anything to this fact).

I believe that research will be coming out in a few months regarding early trials of the topical lotion. It's a long-shot. But at least it is something.

Cheers
Paul
When do they expect the early trial results to be published? Does anyone know how to be included in the clinical trials?

Last edited by IPN1967; 03-05-2019 at 06:11 PM.
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Old 03-05-2019, 07:55 PM   #8
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When do they expect the early trial results to be published? Does anyone know how to be included in the clinical trials?
Results of pilot trial to be published in the next few months.

Phase 2 human trials are currently taking place on human subjects:


Pipeline - WinSanTor

Current focus is on diabetic PN, with an intent to move to chemo- and HIV-related.
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Old 03-05-2019, 10:38 PM   #9
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Originally Posted by Streetlegal View Post
Hi Liqidz--are you sure about that? If you have any links to abstracts of articles I would be very interested.

Cheers
Paul
Here are the complete studies that they have ever done i think compiled into this pdf.
Just click on ''download PDF'' and you'll be able to see it.
If you do a key word search on oral within the pdf,you'll be able to see that it is effective

US2�19��4654�A1 - Treatments for diabetic symmetrical polyneuropathy
- Google Patents





Also i spoke to someone on reddit which stated that they were working on a topical drug for neuropathy which is going really well,didn't state which company or cream ,but pretty obvious :P

We are two scientists and we are walking into a bar AMA! : IAmA

Last edited by liquidz1; 03-05-2019 at 11:21 PM.
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Old 03-06-2019, 12:00 PM   #10
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Two very encouraging quotes from "We are two scientists and we are walking into a bar AMA! : IAmA" link above

"I'm currently working on a topical drug specifically targeting small fiber neuropathy. We are in phase II clinical trials and it's going really, really well. It's a topical drug that should really help with basically no side effects"

"We think our cure works regardless of the etiology behind the neuropathy, but there are some exceptions to this rule"
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