For 5 years I have been using the supplement guidelines posted by Wings 42 on the 2nd page of the Sticky section response #19. (I'll try a link later) in addition to 3600 of Gabapentin (900 every 6 hours). I ski, bike, dirtbike,etc most everyday and function very well as long as I follow the above schedule.
My question for members is there possibly another direction or different approach that may work better for me? I am having success in managing symptoms just wondering if a better approach exists.
Thanks in advance for your valuable opinions

OP: If you have no side effects with this large dose of gabapentin, then stick with it. I know enough who finally got off it due to tremendous side effects. A good friend, but she is not into all the activities you are in, does good with Grape Seed Extract and I've talked about how well Inosine works for me and I too have no desire for all the activities you are into. Personally I'm not a fan of pharma drugs...many do end up with neuropathy due to pharma drugs and many other issues too.

Thanks, I'm reading up on both and will give them a try. Insurance pays for Gabapentin so its basically free, but big pharma appears to want return customers instead of fixing anything. My neuropathy started after radiation for thyroid cancer, but doctors have told me that it's not related. I wonder about the timing though.

OP: Nothing is Free. More and more deaths from drug interactions and procedures every year. Doctors say whatever they want their patients to hear, I don't trust the medical industry. I've been around a long time and have seen and gone thru a lot myself and loved ones and friends.

After I just posted to you I thought of this story from a friend. She's gone thru yrs of radiation for cancers on her legs and ended up with with HORRID yrs of neuropathy and all her doctor would say to her, don't know what the neuropathy is from. She was NOT SMART enough to see thru this MD. She trusted docs, their medicine and believed them....she finally got on grape seed extract and got off the gab...

Caroline 2, I'm giving inosine a try and I really like it so far. Thank you for the recommendation. I will update after a while but I think its a winner

Good and read other reviews too.

Hi ricky, any updates on how inosine is working for you?

Still working with the Inosine. Having difficulties finding dosage instructions related to neuropathy. When I take 1500 I can actually feel circulation in my feet and lower legs for the first time in years. Without proper guidance, I am hesitant to take that large of a dose on a regular basis.
The information I have been able to find is very vague on dosage. Any members able to point me in the right direction?

The whole literature on Inosine is vague, frankly. From my limited understanding it is a chemical developed by the Eastern Bloc in the 1970s to enhance athletic performance. It was developed as a cheat drug and remains a dubious ingredient in the body building world. There is no evidence to support it's efficacy with respect to any sport. Any claims made are false.

However it has been show to promote nerve regeneration and has been used to treat MS and Parkinson's and as a potential pain reliever. I bought it on the strength of Caroline2's recommendation at the height of my symptoms. Due to Covid 19 lockdown and, I think it was imported from USA, it took over a month to arrive by which time my symptoms had subsided somewhat.

I have Swanson Inosine 60 veggie capsules 500mg. The "suggested use" is 'Take one capsule two times per day with water.' The Swanson Website itself makes vague claims about the benefits of Inosine and there are five 5 star reviews that smack of fakery. However Inosine is cheap and HealthMonthly.co.uk effectively delivered it for free such was the delay.

I can't find any upper dosage or toxicity information about Inosine. In the study quoted below they inject mice with 70mg/kg Inosine suggesting you are nowhere near a large dose.

I have taken maybe 1 or 2 tablets a day for about a month and have not noticed anything. But nerve regeneration is a slow process and did not expect to. I am astonished that a supplement like this can have such an effect on you. How can you be so sensitive? How can a chemical that affects nerves act on your blood supply? What is it's duration of action? The only similar experience I have is the effect of a cold shower.( It boosts the immune system) It sends a neural wave down my legs and into my feet. I become very aware of my skeleton for a few seconds.

The problem I have is that I have taken every suggested supplement for PN so I don't know what works, if anything. I will however continue to take Inosine because it has been proven to help nerve regeneration.


Here is a study that finds Inosine promotes nerve regeneration.

Inosine Accelerates the Regeneration and Anticipates the Functional Recovery after Sciatic Nerve Crush Injury in Mice - ScienceDirect.

I would be interested to hear of your continued experience with Inosine and from anyone else.