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Old 09-05-2007, 06:35 AM #13
glenntaj glenntaj is offline
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Location: Queens, NY
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glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default Rina--

I replied to you PM as well, but since you added some stuff here . . .

There are hereditary neural conditions that can "imitate" acquired small-fiber neuroapthies/symptoms and that have predominantly small-fiber effects, although most of them don't have the subacute onset you've described--they tend to come on more gradually.

Still, I would lean towards a small-fiber predominant neuropathy with a possible molecular mimicry autoimmune etiology--you may well have gotten a viral or bacterial infection that your immune system attacked and fought off, but the structure of the pathogen was sufficiently similar to some part of you sensory nerves that the now activated immune system could not distinguish pathogen from self and continued attacking those parts of your nerves. I happen to think this process is more common among people labelled "idiopathic" than most neuros believe.

There are a number of acute/subacute demyelinating neuropathies (inbcluding CIDP variants) that have been associated with previous infection; no reason to assume this could not happen to the axonal fibers as well.

Take a look (at the herediatary areas, especially) at:

http://www.neuro.wustl.edu/neuromusc...ory-small.html

I would think that your doctors could at least look up/try some of the genetic test to "eliminate" known hereditary conditions. I can also say that my QST was normal, but my skin biopsy unequivocally showed small fiber damage--often it depends just WHICH small fibers have been preferentially attacked.
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