--methylcobalamin has been shown to be particularly neuroprotective; it is involved in many of the enzymatic reactions that allow fatty acids to be formed into myelin sheathing. It also may be protective of the biology of the nerve fibers--the axons--themselves.

B12 is not the only vitamin in the B family that is needed for proper nerve functioning--deficiencies of B1 (thiamine), B2 (riboflavin), B3 (niacin), and B6 (pyridoxine) have also been associated with peripheral nerve dysfunction, so a good B-complex is indicated, although one wants to limit megadosing of B6, which can also cause neuropathic symptoms in some people.

Many of us with neuropathies, but without known B vitamin deficiencies, nevertheless think it prudent to take considerably greater doses of B-vitamins than delineated in the USDA minimums; it just makes sense that those with nerve damage, from whatever source, need considerably greater amounts of them for maintenance/repair.

Mark, if you get lessoning of symptoms whilst taken Methlycobalamin that fantastic, but if its repairing the damaged nerves its common to get flaring of symptoms, i found that the flaring were only short periods [they were not really terrible either] but the normal symptoms can persist for a long time but gradually over months the symptoms can get slightly less after some flaring.

Have you had a test for your b12 levels ? but anyway 5mg is a good amount to take, it will NOT hurt you, your body will store what it needs and get rid of any excess, overseas they treat PN with massive amounts per day, its a shame really that some so called medical people don't know nothing about B12 Methylcobalamin supplements, use a good multi B too but don't take it at the same time, its works better that way, if you haven't read Roses site about B12, here is the site - http://roseannster.googlepages.com/home
well worth reading,
good luck with it all anyway,
Brian

Hi, I am taking a normal B-complex, its not particularly strong, I also bought some jarrow formula's B-right from iherb but as I said in earlier post it seems to make the tingling im my feet worse and I was only taking 1 a day, no-one can quite understand how it would do that but I also had the same problem a while back trying a b-100 complex. The normal strength b-complex that I am taking at the moment only has 10mg of b6 , the b-right has 25 mg of b6 + 10 mg of b6 p5p so maybe its that,that is causing the intensified tingling sensations... I am not sure if I am getting enough b vitamins through the normal b-complex ,I guess the only way to get more is to buy each b vitamin separately,avoiding any high dose of b6 unless any other b vitamin could be the cause...

Hi Brian, its all very strange and I am still trying to work out why when I start getting weird sensations in my arm, then why does it also come on in my face at exactly the same time,and my back also feels more numb,it makes no sense. I did start to get less symptoms a few weeks after starting the b12 but now its sort of coming back,I hope it is just a flare up whilst the nerves are repairing,it would be interesting to know the largest amount of b12 taking by anyone in any one day. Like I say in reply to glenn I am not sure if I am taking a strong enough b complex, I really want to take stronger but without too much b6 I guess...

I did have a b12 test,it was in normal range but as of yet I haven't got the exact figure...

Hi Mark,
I don't think it's useful to think about what the largest amount is that was taken by some person in one day.

What's important is finding the right amount for you to be taking.

If you take additional lozenges when you get the symptoms, do they reduce or go away?

That is what would interest me... I'd like to know that.



I hope you are keeping notes of your symptoms, day by day, and not trusting it to your memory...
.

You know what, that image came to mind when I was falling asleep last night. I loved it. The little nerves growing, it was a lovely image to fall asleep to.

Thanks.

(I just wish I'd been able to fall asleep earlier and sleep longer. It irritates me that I am so affected by the stress of the appeal on my condo.)

[QUOTE=Brian;145219]
its a shame really that some so called medical people don't know nothing about B12 Methylcobalamin supplements, use a good multi B too but don't take it at the same time, its works better that way,

Why shouldn't we take the complex B and the Methylcobalamin together?

I read somewhere once that you shouldn't have a B12 shot and a B12 lozenge at the same time...

and I was so careful for the longest time.

But now, I've never been able to detect that to be true...
(true is obviously not the right word - I've failed to go to sleep)

[QUOTE=rina;145374]Hi Rina, Rose could explain it a lot better than i, but what i understand is, when taken it by itself your body hasn't got all that other B vitamins to contend with to metabolize and do its job as well as the B12 too, so taken the b12 by itself at a differant time should give your system an easier job to absorb the vitamin better.
I normally take my Multi B with breakfast, then at lunch i take my b12, its whatever suits the individual though really.
Brian

I will probably try taking 10mg instead of 5mg for a few days and see what happens Karen.Would you know if it is better to take each tablet at a different time or both together? :-)