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Old 12-30-2007, 11:35 AM #11
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Lightbulb there is a theory

cycling in the research biological community that all human disease is
due to some type of viral/bacterial infection. This may cause or trigger the
body changes, but with time I think this will be proven.
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Old 12-30-2007, 11:45 AM #12
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Quote:
Originally Posted by fanfaire View Post
Serotonin syndrome happens to some people much easier than doctors expect. I experienced it when a supposedly reputable shrink switched me from Paxil to Prozac abruptly without telling me that Paxil is long-acting and Prozac is short-acting. Apparently, there was a period of time the Paxil was still in my system along with the Prozac I had just started, which had the same effect as a double dose, and it seriously messed me up.
Actually it is the reverse. But I see your heart is in the right place.
Paxil is very short acting. Elimination half life 21 hrs.
Prozac is 1-3 days depending on the person.

Effexor has one of the shortest half-lives at 5 hrs.

The shorter the half life the harder it is to taper off.

Elimination is also affected by genetic variances in liver enzymes and use of other drugs at the same time. So it can get complicated.

You can get serotonin syndrome by mixing an SSRI with dextromethorphan in cough syrups. (but not everyone does).
People vary in how much serotonin they have. People prone to anxiety disorders, with sensitive traits typically have more. People who get the severe diarrhea and GI side effects when starting, I would think have more serotonin and would be candidates for serotonin syndrome when the drugs are misused or mixed.
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Old 01-22-2008, 09:07 AM #13
Laurie43 Laurie43 is offline
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Quote:
Originally Posted by cyclelops View Post
'I take Neurontin, Cymbalta, Lyrica, Tramadol and 25 milligrams of Topamax at bedtime.'

Did the same physician prescribe all the meds?
Yes hes did... we are trying to take away the amount of Neurontin I am taking. Hopefully, I can get off of it.
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Old 01-23-2008, 12:16 PM #14
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To Laurie43 - Thanks! How long after getting the PN did you get the Fibro?

I have just posted a message on the Fibro board mentioning that I am not on any conventional PN medications yet, as I wanted to get as many tests done to see if we could elicit the cause first. I am taking some other supportive supplements though which you can read about on the CFS/Fibro board, if interested.

Fanfaire - I agree with you that the fatigue is crippling. Pain, burning, muscle fatigue and aches all over etc. are certainly far from pleasant but the fatigue effects everything!

Buttons. Your question re. Mycoplasma. I don't know where I picked it up. Can it come from garden mulch? Just prior to developing the dreadful cough we had been spreading bark mulch on our garden to minimise water evaporation due to our drought and I have wondered whether it could come from damp or mouldy mulch......Anyway I developed a terrible cough in Nov '05 and after a couple of weeks I went to the doc and he tested me for Mycoplasma Pneumoniae as he said that a couple of his other patients had it and it tends to come in clusters. Sure enough - positive result.

Had the appropriate antibiotics (extra long course of Doxycyclin) but the cough persisted for the next ten months. The I had a massive asthma attack and was in hospital for nine days in August 2006. I had five A/B's going at one time, three IV's and two oral, as well as, oxygen, humidifiers, nebulisers and all the asthma drugs. Eventually the attack settled and it took me about three months to get better. Then this year the PN and fatigue started.

In my recent research I have come across many references to Mycoplasma as suspect in causing quite a few sequelae - Fibromyalgia/CFS being one of them. So in looking at the time lines I have been interested in any possible connection between Myco and PN etc.

My research is ongoing and I may never know for sure!


Megan,

Hi, I am sorry it has taken so long for me to write back. My life has been so busy. I have a new job and keeping up with my 13 yr old is challenging. Okay how soon after the PN did I get fibro. It seems like it was only about 6 mos or so. The muscle aches, cramping, trigger points etc... I found a massager that worked miracles and I used it constantly on my hips. It was wonderful. The horrible burning and pain in my butt and hips came in exactly 6 months later. I started Lyrica shortly there after and it was a God send. Not to endorse any medicene, but it has been a miracle drug for me. My life changed drastically for the better. Yes, I have gained 60 pounds now, which is unexceptable. My doc is now slowly taking me off Neurontin. Evidently the combo of Neurontin and Lyrica can trigger even more excessive weight gain. Thanks I say. Anyway, fortunately I was way too skinny to begin with, but now I am starting to be overweight.

Topamax has been added to hopefully help with weight loss. Lyrica is going to stay as it has helped me so much. We will see what happens.

I see a chiropracter as well which has helped with my neck and shoulder pain. He really works on my trigger points, etc..

The neuropathy is the worst though. I can deal with the fibro. The nerve pain is what will get you.

Take care Megan.
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