I do have to agree with Mrs. D. I take R-Lpoic as well. Also, take Synthroid on an empty stomach first thing in the a.m. I do not see any problems stemming from the R-Lipoic while using Synthroid.

The one thing that is most important I have learned, thru experience and internet, DO NOT use a generic for Synthroid. Brand only (synthroid) should be used; never generic. While it may have same ingredients, amounts are different. When I used the levothroxine, it did make a difference in my numbers and showed I needed to raise the amount. I asked my endocronologist to let me stay on the same dose; but change to check Brand Only on my subscription for Synthroid only. Went for blood work three months later; I did not need a change. That was about 3 years ago and have stayed on the same dose continuallyl

I was diagnosed with Hyperthroid (Graves Disease) about 16 years ago. Was treated with tapazole for a few years. Went into remission for a couple of years. I have been hypothroid now for over 5 years. Ever since my throid disease started, about 16 years ago, i have gone to an endocronologist, specializing in throid disease.

Every 4 to 6 months, I have blood work done testing the Throid. Because of this, we have been able to know when I had gone from one, remission; now hyperthroid which I will probably be the rest of my life.

I admit when I first started the R-Lipoic, I would feel a little hyper so I stay on the 100 mg's and do not go any higher. In the hope of the possibility of regenerating nerves, I take MethylCobalamin (Vit. B12), Doctors Best Benfotiamine 150mg's, and Doctor's Best Stabilized R-Lipoic Acid.

I believe my PN is caused by spine surgery over 5 years ago compressing major nerves, plus additional surgeries, bladder, etc. I have not done testing to find out the cause for sure. I don't think it would make any difference.

(Gerry)