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Old 09-21-2012, 08:02 AM #51
bent98 bent98 is offline
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Originally Posted by mjenko View Post
I was on gaba at 2400 mg/d (4x600 mg doses), then switched to Lyrica at 300 mg/day (2x150 mg doses). I found that Lyrica has a half life that tapers off quickly to the point where it is ineffective well before the next dose. I therefore use one gaba to 'fill in' when I start to get very uncomfortable, and it seems to work.


Before I was taking gaba or Neurontin for many years. Then, as most have discovered, the drug's effectiveness diminished rather quickly, hence the titrating up. However, if you can handle occasionally not using these drugs for 1-3 weeks, much if not most of the durgs' original effectiveness returns. I know this creates a roller coaster but for some it may be well worth it.



Mark
How do you wean off so quickly? I assume you need to wean off then wait 1-3 weeks and then ramp back up again?

I was on Gabapentin but could not get past 1500mg a day as it was drying out my throat something God awful.


I am on 600mg lyricia and found that once it hit 300mg I was gettings some positive results that would last a few days. then 400mg. less pain for a week and the pain would come back, 500mg less pain for week, then pain would come back, and then 600mg less pain for a week and pain would come back. Notice a pattern. My Doctor said while you can build up a tolerance to the drug it shouldnt happend that quickly.

My burning pain is up and down so much I can't find a pattern but it seems like the lyrica isnt doing much for it. I should try getting off Lyrica but I am afraid my pain will be worse if I do.
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Old 06-25-2013, 03:55 PM #52
angel04 angel04 is offline
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Hi just read this and thought I would chime in, my Doc changed me from gabapentin 18mg a day on best days to lyrica 300mg morn and night. However after one month on it old problems I had with the feeling in my legs and feet have come back and left me really unsteady when walking. However on the other hand it gave me a sense of well being and I am now going out and meeting with people. I spoke to my dr and he said I should not take gabapentin with lyrica as they are both the same. I beg to differ on gabepentin my pain level was down a lot and I could manage, but my sense of well being was nil, this reversed when I was started on lyrica. Now I am taking both, about 300 mg of the gaba and the 150mg of lyrica, I take the gaba one hour before bedtime and I intend to take it about 2 hours after the lyrica in the morning, I hope I will get the best out of both of them, fingers crossed. I honestly cannot see why they would not work together, they are from the same family and there is definately a difference in the way they work and I am not willing to take my doctors advice as he then told me he had no idea how to help me! so I will see how I go. God bless angel x
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Old 06-25-2013, 11:22 PM #53
MikeB MikeB is offline
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Originally Posted by angel04 View Post
Hi just read this and thought I would chime in, my Doc changed me from gabapentin 18mg a day on best days to lyrica 300mg morn and night. However after one month on it old problems I had with the feeling in my legs and feet have come back and left me really unsteady when walking. However on the other hand it gave me a sense of well being and I am now going out and meeting with people. I spoke to my dr and he said I should not take gabapentin with lyrica as they are both the same. I beg to differ on gabepentin my pain level was down a lot and I could manage, but my sense of well being was nil, this reversed when I was started on lyrica. Now I am taking both, about 300 mg of the gaba and the 150mg of lyrica, I take the gaba one hour before bedtime and I intend to take it about 2 hours after the lyrica in the morning, I hope I will get the best out of both of them, fingers crossed. I honestly cannot see why they would not work together, they are from the same family and there is definately a difference in the way they work and I am not willing to take my doctors advice as he then told me he had no idea how to help me! so I will see how I go. God bless angel x
Hi Angel,
As PN started to build up, my PCP put me on Lyrica. I worked up to 200 mg, 3x with an extra one about 2 hours before bedtime. After a while, the pain build up again was getting excruciating. He added gabapentin. So along with the Lyrica, I'm on gaba 600 mg., 3 x.
I also take Vicodin before bedtime and for "breakthrough" pain, mostly on weekends.
This is what works for me.
Hope this helps.
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Old 07-01-2013, 02:08 PM #54
Siddhi Siddhi is offline
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Originally Posted by groskilly View Post
My Doc switched me from Gabapentin to Lyrica about a month ago. The Gabapentin was no longer helping much with my burning feet. I was at 3600mg of Gabapentin. I continued to take the remaining Gabapentin (300mg caps) here and there along with the Lyrica when the burning was bad and it seemed to help. Eventually I ran out of the Gabapetin and the burning became more intense (worse). I told my Doc I was taking both and he said he never heard of anybody doing that and doesn't recommend it.
A couple of questions.
Does it make any sense at all that the 2 drugs would work better in combination ?
I am taking 375mg of Lyrica and would like to increase the dosage. Does Lyrica have a max dose where the effectiveness peaks out like Gabapentin (3600mg) ?

Gerald
I have Peripheral Neuropathy. Tried Lyrica, Cymbalta, Gabapentin, ALL OF THE SERATONIN REUPTAKE INHIBITORS.

They all make me deathly sick. I'm bad with pills or they're bad with me!

Pain in arms and legs. Ride my recumbent bike every day. Do Yoga stretches that's I'm still able to do. Have to use a walker so I go outside and take a "walker" walk when the weather is okay.

Lots of Vitamin B and Alpha Lipoic Acid.

It's a real bummer!

Siddhi
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Old 07-02-2013, 10:58 PM #55
Wreck_Tangle Wreck_Tangle is offline
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Originally Posted by mrsD View Post
Is that even though Neurontin and Lyrica are similar, they must work slightly differently at the cell membrane level.

People who are on Neurontin for a while, the nerves get "used" to that way, and when you introduce the new Lyrica, either it doesn't get "in" the same, perhaps the Neurontin blocks it, or the nerves just have to "learn" to use the Lyrica
slightly differently. In other words an adjustment period occurs.

These drugs are not identical, and the body tends to "get used to things" and readjust etc. It does this with many other types of drugs too.

Oh boy.. As some might have read in another thread, I have to wait 2 months for my Lyrica. I called my Doc. last week and asked her to think about letting me take the Gabapentin. They finally called today and she said yes to it.

Now after reading this, is it even a good idea? Should I just wait it out, or deal with the 'big switch' when the time comes?

My pain level every day is a 9-10, along with that lovely swelling and burning feeling in my feet/legs.
My pain isn't only lower body though, it stems from my neck all the way down to my toes.
As of right now, I have another month to go till I get my Lyrica.
Someone at the pharmacy messed up and told me a month, when it's actually 2 months.

My situation.....I prepay the pharmacy for 3 months worth, and the drug company is giving it to me. I have no insurance and this is how they deal with people on low income/no insurance if you're approved.
I guess i am also going to have to talk to someone from the pharma. co. as well when they call me.
This is all so new to me. =/
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Old 07-06-2013, 10:07 PM #56
joecarver joecarver is offline
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Just being increased to 300 Lyrica, no side effects so far, wish me luck I need it
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