Here is an interesting site. Statins are contraindicated for people who have CMT.

http://help4cmt.com/articles/?id=35&...terol-with-cmt

The general population can also have trouble with statins such as muscle pain, weakness, etc. I know people who have experienced this. This site might help and there are many sites out there.

http://www.mayoclinic.com/health/sta...ffects/MY00205

Despite the fact that you have had a negative genetic workup and a negative family history, you still could have a type of CMT. Symptoms can vary greatly even within the same family. They can be hardly having any symptoms that are noticeable at all. There could be a spontaneous mutation which is rare.

I just heard about PQQ, which a search on this board indicated has not been discussed previously.

"PQQ’s powerful free radical–scavenging capacity provides the mitochondria with superior antioxidant protection due to its high molecular stability and the role it plays in energy transfer directly within the mitochondria.

"Unlike other antioxidants, the exceptional molecular stability of PQQ allows it to carry out thousands of electron transfers without undergoing molecular breakdown.

"PQQ is especially effective in neutralizing superoxide and hydroxyl radicals, two prominent causes of mitochondrial dysfunction.

"According to a University of California at Davis study, “PQQ is 30 to 5,000 times more efficient in sustaining redox cycling (mitochondrial energy production) . . . than other common [antioxidant compounds], e.g. Ascorbic Acid (Vitamin C).”

http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone

It sounds too good to be true, but I'm going to try some anyway.

This is the stunning part:

"In 2010, researchers at the University of California at Davis released a peer-reviewed publication showing that PQQ’s critical role in growth and development stems from its unique ability to activate cell signaling pathways directly involved in cellular energy metabolism, development, and function.

"Most significantly, the study demonstrated that PQQ not only protects mitochondria from oxidative stress—it promotes the spontaneous generation of new mitochondria within aging cells, a process known as mitochondrial biogenesis.

"The implications of this revelation for human health and longevity are significant because the only other known methods proven to stimulate mitochondiral biogenesis in aging humans are intense aerobic exercise, strict caloric restriction, and certain medications such as thiazolidinediones and the diabetes drug metformin."

This is very good news for me and others whose chronic fatigue has not allowed intense aerobic exercise.

There also appear to be other significant neuro benefits to PQQ.

I agree it sounds very interesting. Let us know how you do.

I am in the middle of trying N-A-G... and a new histamine blocker (which just arrived, and waiting a bit to start). So I don't want to introduce a "new" thing at this time, which may confound the results of the NAG, etc. I have given the Daosin histamine blocker to Oreo twice--- a 1/3 capsule, and she seems comfortable so far. (she has that mast cell (histamine secreting tumor).

Let us know how you do. PQQ doesn't seem very expensive either!
I wonder why we don't hear more about it?

As far as statin toxicity goes... the mito issues may be a direct thing, or indirect. Since statins block our ability to normally make CoQ-10, and CoQ-10 is essential to mito functions, it may be this effect indirectly.

But since Big Pharma tends to release some of the negative studies on their patented products, after the patents expire, we may soon see some interesting (and horrifying) things.. As long as Pfizer pays people to ask for BRAND Lipitor, this will be delayed. This new ploy of theirs is unique in the industry. See the commercials on the Lipitor copay card? I wonder if it will work?

That is very interesting. Are you on any other medications? I am wondering about the contraindications. I think I would really like to give this a try. I am one of those with no energy. Thanks for the info!

I don't think you'll find this PQQ on any drug checker.

It is not mainstream yet.

Here is a drug checker that is pretty good:
http://www.drugs.com/drug_interactions.html

The most serious interactions involve warfarin for any supplement, so anyone here on warfarin (Coumadin), should
discuss with your doctor.

Thanks Mrs. D. I am not taking any anti-coagulants so I think I may try PQQ. Do you or Neurologic mention wher you can buy it? I am off for the holiday next week and may try this.Thansk!

This Amazon entry has 3 choices...2 with free shipping. Net Rush has better customer satisfaction:

The 3rd is Amazon itself, with the 25 dollar free shipping.
These are the most reasonable IMO.

This one only has .75 shipping:
http://www.amazon.com/gp/product/B00...8JCVYNN03QPB33

I'd start at 10mg a day. There is really no dosage scale available for this yet.
As you can see from this food content chart, the food content ranges in micrograms. 10mg =10,000 micrograms

hopeful - I just wan't to be sure you let us know how the PQQ worked for you. If I don't keep this thread highlighted, with all the meds I am on I will forget which one I am trying to follow and not know which one is about what ! I am really interested in the PQQ/CoQ10 supplements and would like to try them if/when life settles down...

Interesting my pn symptoms started with a bang after being put on Amoxicillin and Metoclopramide .

What do you think of this Mrs D?

Merry Christmas to you and of course everyone else here .

m

After some antibiotics... Candida can grow in the GI tract.
This releases toxins into your blood, mostly aldehydes.

Trying Benfotiamine is a good idea. Since thiamine it a cofactor in alcohol and aldehyde degradation.