advertisement
Reply
 
Thread Tools Display Modes
Old 04-19-2009, 01:36 PM #1
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Confused Issues with B12

Trying again to post this. Wondered if anyone knew any contraindication for using sublingual B12. I seem to recall a post somewhere that indicated that sometimes the sublingual form should not be used in cases of certain neuro diseases.
Anyone have any info on this?
Karen S is offline   Reply With QuoteReply With Quote

advertisement
Old 04-19-2009, 02:58 PM #2
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Quote:
Originally Posted by Karen S View Post
Trying again to post this. Wondered if anyone knew any contraindication for using sublingual B12. I seem to recall a post somewhere that indicated that sometimes the sublingual form should not be used in cases of certain neuro diseases.
Anyone have any info on this?
If a person is hugely deficient and near death, a series of daily injections of cyano is required to prevent death. I see this in nursing homes frequently. By the time patients get to long term care they are very very ill...near death.

For those patients living a life...walking/talking breathing, etc, oral B12 (not necessarily sublingual) will do as well. Sublingual claims are not sterling. Most of what dissolves in your mouth is swallowed with your saliva.

Take at least 1000mcg (1mg) daily on an empty stomach, and you'll do as well as injectable. Studies have confirmed this.
If you are very low, you can do 5mg daily for a month or two...and decrease to 1mg daily after that. Don't assume you will be ever off it...it is most likely a lifetime thing. Whatever has caused your low readings is not going to change.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
mrsD is offline   Reply With QuoteReply With Quote
Old 04-20-2009, 11:02 PM #3
Silent2 Silent2 is offline
Junior Member
 
Join Date: Apr 2009
Posts: 7
15 yr Member
Silent2 Silent2 is offline
Junior Member
 
Join Date: Apr 2009
Posts: 7
15 yr Member
Default

I do not know about a nuero problem, but if you have colitis, you might not be able to take the sublingual kind because it contains artificial sweeteners. If I can be of help, just let me know.

Best,

Silent
Silent2 is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 12:00 AM #4
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Default Silent 2

Thanks for trying. I appreciate the responses I have received. I guess I will just have to keep trying to find the info. I was able to learn a good bit by searching various sites, but not about a neuro contraindicaton for the sublingual form.
I guess I have learned that when I see something like that, I need to write it down.
Karen S.
Karen S is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 12:40 AM #5
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Quote:
Originally Posted by Karen S View Post
Thanks for trying. I appreciate the responses I have received. I guess I will just have to keep trying to find the info. I was able to learn a good bit by searching various sites, but not about a neuro contraindicaton for the sublingual form.
I guess I have learned that when I see something like that, I need to write it down.
Karen S.
One has to be careful on the net.
The only "negative" thing I can think of (and I did a Google search just now which showed nothing)
is the Pfeiffer research. People with methylation errors..
MAY have certain needs that differ from others.
Bipolar disorder for example is a methylation disorder it is thought.
http://www.alternativementalhealth.c...es/walshMP.htm
Check the section on "methylation". Not many doctors agree with the Pfeiffer institute, however.

B12 is part of a group of B vits that work together. Ignoring the others, results in less improvement. B6 and folate are both needed to help reduce homocysteine, and if those are low, then homocysteine continues to damage the blood vessels.

The risk of B12 deficiency is high in older patients. That is why guidelines suggest all persons over 50 take a supplement now.

When you find what you are looking for, please post it here.
I'd like to see it.

This is the typical warning to NOT use FOLATE in B12 deficient patients:
Quote:
Large doses of folic acid given to an individual with an undiagnosed vitamin B12 deficiency could correct megaloblastic anemia without correcting the underlying vitamin B12 deficiency, leaving the individual at risk of developing irreversible neurologic damage (6). For this reason the Food and Nutrition Board of the Institute of Medicine advises that all adults limit their intake of folic acid (supplements and fortification) to 1000 mcg (1 mg) daily.
Perhaps this is what you read?
This quote is from http://lpi.oregonstate.edu/infocente...ns/vitaminB12/
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.

Last edited by mrsD; 04-21-2009 at 12:58 AM.
mrsD is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 08:34 AM #6
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

I just recalled one thing I remember from a Mayo site
regarding the rare hereditary disorder called Leber's optic
neuropathy.

The Mayo site is not accurate on this subject. It was previously thought that B12 could not be used in these patients (who tend to all have low levels ) but newer information states that it is the CYANO form that should not be used. Recommended form for these patients is hydroxy or methyl.
I could not find any sites besides the Mayo one that says not to use B12. They ALL have B12 as treatments (except for the cyano version).

So if you find an older site or one that uses old information you might find Leber's listed as a condition to not use B12.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
mrsD is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 12:09 PM #7
Patricialyn Patricialyn is offline
Junior Member
 
Join Date: Aug 2006
Location: In the country in WNY, near Lake Ontario.
Posts: 33
15 yr Member
Patricialyn Patricialyn is offline
Junior Member
 
Join Date: Aug 2006
Location: In the country in WNY, near Lake Ontario.
Posts: 33
15 yr Member
Default Questions?

Hello Friends,

Ok, I am still a bit confused? I was diagnosed with vitamin B12 deficiency, and D as well as I posted before.

However I am questioning the B again.

1. Is the methyl B12 the same as the B12 you place under your tongue? That's interesting that the B12 that you take under your tongue has artificial sweeteners in it. I try to stay away from them for many reasons, one I get migraines and it is noted that they can trigger migraines.

2. Is there a vitamin B12 pill, that can give me just as much benefits as the shot of B12 that I can receive from my Dr.

3. If any, what are the benefits of Vitamin B12 shots.

4. Approximately How long does it take to see a noticeable difference after receiving vitamin treatments?

Thanks...

Patty
Patricialyn is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 12:33 PM #8
mrsD's Avatar
mrsD mrsD is offline
Wisest Elder Ever
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

There are several types of methylcobalamin on iherb.com

Some with NO sweeteners of any kind.

You don't have to place the sublinguals under the tongue. You can swallow them. (in fact that is what happens anyway...you swallow your saliva eventually with the B12 in it).

The oral use is as good as the injectable. I have put up papers that have shown this to be accurate, in the past. Here are two examples:

Quote:
Am Fam Physician. 2009 Feb 15;79(4):297-300.Links
Evidence for the use of intramuscular injections in outpatient practice.
Shatsky M.

Providence Medical Group, Portland, Oregon, USA. mlsdo2000@comcast.net

There are few studies comparing the outcomes of patients who are treated with oral versus intramuscular antibiotics, corticosteroids, nonsteroidal anti-inflammatory drugs, or vitamin B12. This may lead to confusion about when the intramuscular route is indicated. For example, intramuscular ceftriaxone for Neisseria gonorrhoeae infection and intramuscular penicillin G benzathine for Treponema pallidum infection are the treatments of choice. However, oral antibiotics are the treatment of choice for the outpatient treatment of pneumonia and most other outpatient bacterial infections. Oral corticosteroids are as effective as intramuscular corticosteroids and are well-tolerated by most patients. High daily doses of oral vitamin B12 with ongoing clinical surveillance appear to be as effective as intramuscular treatment. Few data support choosing intramuscular ketorolac over an oral nonsteroidal anti-inflammatory drug unless the patient is unable to tolerate an oral medication. For other indications, the intramuscular route should be considered only when the delivery of a medication must be confirmed, such as when a patient cannot tolerate an oral medication, or when compliance is uncertain.

PMID: 19235496 [PubMed - indexed for MEDLINE]
from http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

Quote:
Fam Pract. 2006 Jun;23(3):279-85. Epub 2006 Apr 3.Click here to read Links
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials.
Butler CC, Vidal-Alaball J, Cannings-John R, McCaddon A, Hood K, Papaioannou A, Mcdowell I, Goringe A.

Department of General Practice, Cardiff University, Wales, UK.

BACKGROUND: Vitamin B(12) deficiency is common, increasing with age. Most people are treated in primary care with intramuscular vitamin B(12). Several studies have reported equal efficacy of oral administration of vitamin B(12). OBJECTIVES: We set out to identify randomized controlled trial (RCT) evidence for the effectiveness of oral versus intramuscular vitamin B(12) to treat vitamin B(12) deficiency. METHODS: We conducted a systematic review searching databases for relevant RCTs. Outcomes included levels of serum vitamin B(12), total serum homocysteine and methylmalonic acid, haemoglobin and signs and symptoms of vitamin B(12) deficiency. RESULTS: Two RCTs comparing oral with intramuscular administration of vitamin B(12) met our inclusion criteria. The trials recruited a total of 108 participants and followed up 93 of these from 90 days to 4 months. In one of the studies, mean serum vitamin B(12) levels were significantly higher in the oral (643 +/- 328 pg/ml; n = 18) compared with the intramuscular group (306 +/- 118 pg/ml; n = 15) at 2 months (P < 0.001) and 4 months (1005 +/- 595 versus 325 +/- 165 pg/ml; P < 0.0005) and both groups had neurological responses. In the other study, serum vitamin B(12) levels increased significantly in those receiving oral vitamin B(12) and intramuscular vitamin B(12) (P < 0.001). CONCLUSIONS: The evidence derived from these limited studies suggests that 2000 microg doses of oral vitamin B(12) daily and 1000 microg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short-term haematological and neurological responses in vitamin B(12)-deficient patients.

PMID: 16585128 [PubMed - indexed for MEDLINE]
from http://www.ncbi.nlm.nih.gov/sites/en...&term=16585128

Why anyone today would choose invasive costly injections, over a simple oral method is beyond me. Those needles can inflame deeper tissues, and if misplaced can cause nerve damage!

Methyl injections are available, but have to be compounded at a higher cost.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei

************************************

.
Weezie looking at petunias 8.25.2017


****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.

Last edited by mrsD; 04-22-2009 at 08:52 AM. Reason: fixing link
mrsD is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Karen S (04-21-2009)
Old 04-21-2009, 01:37 PM #9
Patricialyn Patricialyn is offline
Junior Member
 
Join Date: Aug 2006
Location: In the country in WNY, near Lake Ontario.
Posts: 33
15 yr Member
Patricialyn Patricialyn is offline
Junior Member
 
Join Date: Aug 2006
Location: In the country in WNY, near Lake Ontario.
Posts: 33
15 yr Member
Default

Hello again,

Thank you so much for you excellent post filled with the information I was looking for. However I have to admit I had to read it a few times to truly let it sink in.

Your are absolutely correct in my opinion about the negative in receiving a shot of B12, verses the other options.

I plan to take the B- complex that I already have, not to be wasteful, then buy the oral B that have a higher mg.

Patty
Patricialyn is offline   Reply With QuoteReply With Quote
Old 04-21-2009, 04:37 PM #10
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Karen S Karen S is offline
Junior Member
 
Join Date: Jan 2009
Location: Canton GA
Posts: 10
15 yr Member
Thumbs up For Mrs. D:

Wow and thanks so much for going to the trouble to dig out that info!
One of my docs was pushing for the IM version and your info gives me more ammunition. I have read that the cerobrospinal fluid is the only truly accurate measurement of B12 in the system, but who wants to go there?
This was a very valuable posting.
Karen
Karen S is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Hi...I've got issues. Macophile New Member Introductions 9 08-06-2008 06:56 PM
Med Issues? daniella Medications & Treatments 0 06-20-2007 06:09 AM
Med Issues? daniella Peripheral Neuropathy 3 06-18-2007 02:06 PM
l-4 issues taino Spinal Disorders & Back Pain 2 01-31-2007 04:00 PM
Well, we must have some issues Alffe Women's Health 13 09-20-2006 11:09 PM


All times are GMT -5. The time now is 12:01 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.