One other thing to mention--
 

--about that low IgA level--while the genetic profile that results in low overall IgA is not uncommon, it can have a skewing effect on the Celiac/gluten sensitivity tests, particularly the IgA anti-Gliadin and IgA anti-transglutaminase tests (the latter is more specific for the villious intestinal damage of frank Celiac). Low IgA levels may mean that one can get a "false negative" on these IgA measurements--there may simply not be enough IgA antibody being produced by these to measure, and therefore some people may have celiac/gluten sensitivity without showing up positive on these.

JCC's The Gluten File has info on this, as well as alternative testing that is sometimes done in such situations:

http://neurotalk.psychcentral.com/thread1872.html

Yes, in general I'm very pleased with my blood test results and quite relieved that my homocysteine level was normal.

I'm trying to do more research on the Pyrolurria. What really confuses me is that my B-6 blood test came back totally normal. i was not tested for zinc or copper. I don't have any signs of zinc deficiency as far as I can tell....no white spots on my fingernails, for example. So I'm really kinda confused about the results of the Pyrolaurria urine test.

I had myself tested on a whim. I mainly want my teenage daughter to be tested, because she has developed an anxiety disorder with symptoms of de-realization. I know it sounds rather schizophrenic, but our therapist assures us that it's anxiety related. So through research, I discovered Pyrolaurria and wanted her to get tested for it. Schizophrenia runs in my husband's family (his late sister, and mother).

Anyway, I'm not keen on my 15-year-old taking pharmaceuticals. She is handling her symptoms with therapy -- has good grades, friends, etc. (BTW, if she REALLY needed pharmecuticials I would take her to a psychiatrist...but I know enough about the drugs to know that I don't want to start her on that path just yet). I had an inkling that maybe she had Pyrolaurria. I had her start taking my B-Complex vitamin, as well as some extra calcium and magnesium, and a multi-vitamin. She said it has really helped and her symptoms diminished somewhat. But to go OFF her vitamins to get tested for Pyrolaurria was very difficult for her. She made it almost a week and said that her symptoms had returned and gotten worse. She had some important tests at school and decided to go back on her vitamins so that she could concentrate.

So we're waiting until Thanksgiving Break for her to go off her vitamins and finally do the urine test for Pyrolaurria. Now that I know that I apparently have it, there is a really good chance that she has it, too.

I'm getting a second opinion for myself from a more holistic group of doctors in my area who deal with thyroid and hormone issues. They are called the Holtorf Group, and are mainly based in S. Cal but have an office where I live in N. Calif. I need to call them today to see if they deal with Pyrolaurria.

Anyway, some of this really makes sense to me. When I am stressed-out, it seems that my entire "system" gets totally out of whack. I don't sleep well, have heart palpitations, some mental issues.....now I understand this cycle a little better. I feel like some pieces of the puzzle may be falling into place.

I also need to investigate that IGA thing more thoroughly, as well. Truthfully I don't think that i have a gluten problem, but I want to know for sure. My Endocrinologist apparently doesn't understand it well enough to recommend any other testing for me.

Hey, I'd appreciate if somone could answer this ASAP.

Can too much B-12 cause ringing in the ears, a racing heart, and feelings of anxiety or panic?

The past few days I've had these symptoms.

I have a dental procedure (gum grafting) coming up on Monday that I'm stressed out about. At first I thought it was that....but honestly it feels more "organic" to me than just being anxious about this procedure. I'm having trouble sleeping and feel as if I've had too much caffeine (I don't drink ANY caffeine or take ANY stimulants because they make me jumpy)

I assume that if I have been over-doing it with the B-12, maybe it will just go out of my system after a few days and I'll feel better soon?

I have gone as far as taking some Ativan, but it doesn't seem to be calming me down much....which is very weird because usually it works very well and even puts me to sleep.

I have decided today to take a break from all of my vitamins and also my Synthroid. This feels a little bit like over-replacement of thyroid hormone, but it's hard to tell. It actually feels worse than when my Synthroid is too much....my heart is racing constantly these past few days. The only thing I can think of is that I've been taking the 5,000 mg of B-12 every day, and maybe at this point that's too much for me now that my level has gotten somewhat corrected?

@zee: I have not had any problems with B12, and I am taking more than you are.

Hope that helps.

I was getting that from too much R-lipoic acid. I am back down to 100mg a day...stablilized form.

You could always just cut back if you want... to use up the 5mg just take it twice a week for now. When you get 1mg, you could do that daily.

I also get hyper on folic acid...I don't take much of that at all anymore.

I am taking the Methycoblamin B12 lmg and it works good. I also am on the R-lipoicAcid (100mg). I had been on the Methyl B12 for about 4 weeks before adding the R-Lipoic Acid.

I gradually noticed much more energy and was loosing a few pounds. It has been about 2 months with R-Lipoic and I have lost between 8 - 10 lbsl (varies). I can't imagine going any higher than 100 Mg's. I do believe that has also added additional anxiety. I am taking these, in addition to the Bentofolamine (B1) in the hope of regenerating nerves. (some success has been noted by some). I will stay on this regimein for the possible nerve regenerating.

Also, I believe a poster said they had gone off vitamins, including Synthroid. I hope the endocrinologist is aware of stopping the Synthroid. That is something not to just abruptly stop.

I didn't stop my Synthroid, only my vitamins.

When you get your thyroid levels tested, you should not take the Synthroid the morning of the test. Or additionally you can skip one previous day as well. But no more than that.

I do believe it was the B-12 that was making me jumpy. After not taking it for a few days, the anxiety started to settle down. Then I got some exercise, and had some orange juice (for the potassium), and between those two things the anxiety level went way down and then I was feeling normal again.

I just had my gum grafting surgery today and it went well. The inside of my mouth is all stitched up and I'm staying ahead of the pain with tylenol or ibuprofen (not together). I will probably continue to take a break from B-12 for a few days and then resume with the 1,000 mg and all my regular stuff.

Do any of you know anything about Pyrolurria? I just found out that I have it via a urine test. It causes malabsorption of B-6, Zinc, and a few other minerals. I'm in the process of trying to find a doctor who knows how to treat it. I have read that people with Pyrolaurria need to take P5P in addition to regular B-6. Luckily, my B-complex vitamin DOES have P5P, although not in the dose recommended to treat the condition. It's considered controversial. Some MD's don't believe that it exists. Naturopaths mainly treat it, but there are a few MDs who understand it, such as group called the Pfeifer Center in the Chicago area. (But I live in California).

What pyroluria does is increase excretion of the B6 and zinc.
This is because the pyrroles made by the liver in error, complex these two nutrients so they become unavailable to your other tissues for the work they do.

So taking extra is the solution. One has to watch high zinc intake because over time, it can block copper utilization and some believe manganese as well. So doctors test the minerals periodically in the blood. Also very high zinc over time can cause neuropathy. Low zinc tends to cause slow wound healing of the skin and lowered immunity to viruses and bacteria.
Some drugs actually deplete zinc... ACE inhibitors for blood pressure, diuretics, some antivirals, hydralazine, acid blocking drugs.

I never get the "energized" B12 reactions, for some reason.
But I suppose in people who start out very low (I have fairly normal levels), the switch to higher will energize your metabolism some. When you take oral, daily, the amount really absorbed it not high. People with intact intrinsic factor may absorb more. B12 is excreted in the bile, and eliminated.

I guess I misunderstood when you mentioned you decided to take a break from all your vitamins and also synthroid.

Hi, mrsD! I posted a thread here a while back about my small fiber neuropathy, and the other members told me you were on vacation at the time, but I was wondering if there was anything you could suggest for me. Many thanks!

The end of the URL is thread154928.html, title "Small fiber neuropathy not getting better or worse - advice?" (sorry, it won't let me post a link!)