[mrsD]

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

Emisphere's pharmacokinetic study demonstrated that mean Vitamin B12 peak blood levels were more than 10 times higher for the Eligen® B12 5mg formulation than for the 5mg commercial formulation (12847 pg/ml and 1239 pg/ml, respectively). The time to reach peak concentration (Tmax) was reduced by over 90%; the mean was 0.5 hours for the Eligen® B12 5mg and 6.8 hours for the commercial 5mg product. Mean AUC_(24h) values were 54618 for Eligen® B12 and 23131 for the commercial 5mg product. Improvement in bioavailability was approximately 240%, with absorption time at 30 minutes. The study was conducted with a single administration of Vitamin B12; there were no adverse reactions, and Eligen® B12 was well-tolerated.

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.