[mrsD]

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

Emisphere's pharmacokinetic study demonstrated that mean Vitamin B12 peak blood levels were more than 10 times higher for the Eligen® B12 5mg formulation than for the 5mg commercial formulation (12847 pg/ml and 1239 pg/ml, respectively). The time to reach peak concentration (Tmax) was reduced by over 90%; the mean was 0.5 hours for the Eligen® B12 5mg and 6.8 hours for the commercial 5mg product. Mean AUC_(24h) values were 54618 for Eligen® B12 and 23131 for the commercial 5mg product. Improvement in bioavailability was approximately 240%, with absorption time at 30 minutes. The study was conducted with a single administration of Vitamin B12; there were no adverse reactions, and Eligen® B12 was well-tolerated.

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.

[MelodyL]

Originally Posted by mrsD

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.

Mrs. D.

I clicked on the emisphere link and read the info.

How exactly is the DELIVERY of this oral B-12 different than what I am doing presently. Taking the Jarrow 5000 sublingually each morning.

Thanks much

Melody

[mrsD]

The new system is vague...they don't want to reveal their patent IMO.

One of the links shows how their additive enables large molecules to cross membranes in the GI tract.
Up until now, if you have no intrinsic factor working, high dose B12 is only passively absorbed in the intestine. This is why high doses are needed, to push a little bit (less than 10%) into the blood stream. This is why empty stomach is important now with the oral as it exists today.

It appears this technology is going to be applied to insulin and other large molecules that cannot be given orally at this time due to stomach acid and poor absorption.

It appears that the B12 is the first application for this. I guess it will generate some income to support the research for the other uses.

I just hope it is not priced so high as to be out of many peoples' reach. And I couldn't find what type of B12 they are doing either.
I hope it is methylB12.

I think those questions will resolve soon, as it will be out soon.