[AlwaysLearning]

Originally Posted by MelodyL

Hi, I started taking 5000 of the Methyl B-12 over 2 years ago. Best thing I ever did for my neuropathy. I now take it about 3 times a week.

Hope it works for you the same way it worked for me.

Take care

Melody

My multi has B-12 in the methyl flavor, but I have been taking it with food
I'm hopeful I'll have similar results as you.
Thanks for your comment.

[MelodyL]

Originally Posted by AlwaysLearning

My multi has B-12 in the methyl flavor, but I have been taking it with food
I'm hopeful I'll have similar results as you.
Thanks for your comment.

It should be taken on an empty stomach. I began with 1000 once a day and after one week I knew I had to take the 5000. I started with iherb.com and now we get all our stuff from Puritans because of the buy 2 get 3 free offers.

So far, so good.

Wishing you well!!!

Melody

[zeeclass6]

Just wondering -- is it better to split up your B-12 dose during the day, or take it all at once in the morning? I just upped my dose to 5,000 mg of methyl and wasn't sure if I should cut it in half and take half in the morning on an empty stomach, and half in the afternoon two hours after lunch.

In theory, could taking some B-12 in the early afternoon give you more energy for late in the afternoon? Or does it really not matter?

[mrsD]

It is better to take all at once... on empty stomach.

If you have intact intrinsic factor this is less of an issue.

But those who show up here with lows, have some problem or they would not be low and have the neuro symptoms.

When intrinsic factor is not working (for whatever reason), the only way B12 is absorbed is by passive osmosis thru the lining of the GI tract. The higher the concentration present, the more that will get thru. 5mg will result in more being absorbed, which is still a very small amount. 1mg also is absorbed, but 5 times less than the larger dose.

Some things have receptors controlling absorption, or a biochemical barrier. Zinc, magnesium, calcium, carnitine, Neurontin, are examples of limited absorption, needing perhaps divided doses.