[ger715]

Originally Posted by mrsD

I was getting that from too much R-lipoic acid. I am back down to 100mg a day...stablilized form.

You could always just cut back if you want... to use up the 5mg just take it twice a week for now. When you get 1mg, you could do that daily.

I also get hyper on folic acid...I don't take much of that at all anymore.

I am taking the Methycoblamin B12 lmg and it works good. I also am on the R-lipoicAcid (100mg). I had been on the Methyl B12 for about 4 weeks before adding the R-Lipoic Acid.

I gradually noticed much more energy and was loosing a few pounds. It has been about 2 months with R-Lipoic and I have lost between 8 - 10 lbsl (varies). I can't imagine going any higher than 100 Mg's. I do believe that has also added additional anxiety. I am taking these, in addition to the Bentofolamine (B1) in the hope of regenerating nerves. (some success has been noted by some). I will stay on this regimein for the possible nerve regenerating.

Also, I believe a poster said they had gone off vitamins, including Synthroid. I hope the endocrinologist is aware of stopping the Synthroid. That is something not to just abruptly stop.

[zeeclass6]

I didn't stop my Synthroid, only my vitamins.

When you get your thyroid levels tested, you should not take the Synthroid the morning of the test. Or additionally you can skip one previous day as well. But no more than that.

I do believe it was the B-12 that was making me jumpy. After not taking it for a few days, the anxiety started to settle down. Then I got some exercise, and had some orange juice (for the potassium), and between those two things the anxiety level went way down and then I was feeling normal again.

I just had my gum grafting surgery today and it went well. The inside of my mouth is all stitched up and I'm staying ahead of the pain with tylenol or ibuprofen (not together). I will probably continue to take a break from B-12 for a few days and then resume with the 1,000 mg and all my regular stuff.

Do any of you know anything about Pyrolurria? I just found out that I have it via a urine test. It causes malabsorption of B-6, Zinc, and a few other minerals. I'm in the process of trying to find a doctor who knows how to treat it. I have read that people with Pyrolaurria need to take P5P in addition to regular B-6. Luckily, my B-complex vitamin DOES have P5P, although not in the dose recommended to treat the condition. It's considered controversial. Some MD's don't believe that it exists. Naturopaths mainly treat it, but there are a few MDs who understand it, such as group called the Pfeifer Center in the Chicago area. (But I live in California).

[mrsD]

What pyroluria does is increase excretion of the B6 and zinc.
This is because the pyrroles made by the liver in error, complex these two nutrients so they become unavailable to your other tissues for the work they do.

So taking extra is the solution. One has to watch high zinc intake because over time, it can block copper utilization and some believe manganese as well. So doctors test the minerals periodically in the blood. Also very high zinc over time can cause neuropathy. Low zinc tends to cause slow wound healing of the skin and lowered immunity to viruses and bacteria.
Some drugs actually deplete zinc... ACE inhibitors for blood pressure, diuretics, some antivirals, hydralazine, acid blocking drugs.

I never get the "energized" B12 reactions, for some reason.
But I suppose in people who start out very low (I have fairly normal levels), the switch to higher will energize your metabolism some. When you take oral, daily, the amount really absorbed it not high. People with intact intrinsic factor may absorb more. B12 is excreted in the bile, and eliminated.

[ger715]

I guess I misunderstood when you mentioned you decided to take a break from all your vitamins and also synthroid.