[chefaid90]

so would a level of 330 be concidered low enough to cause major problems?

[chefaid90]

Originally Posted by chefaid90

so would a level of 330 be concidered low enough to cause major problems?

forgot to add thanks for all the info.

[mrsD]

Originally Posted by chefaid90

so would a level of 330 be concidered low enough to cause major problems?

Most definitely. This is below the cut off of 400... and even 400 may still be too low for neuro symptoms.

See post #70 here for details.

[mrsD]

Originally Posted by Nervous

I just scooped this off the net:

"Normal values are 200 - 900 pg/mL (picograms per milliliter)."

http://www.nlm.nih.gov/medlineplus/e...cle/003705.htm

But mrsD may have better info.

This is typical showing the low end as "normal" which it is not.

http://www.aafp.org/afp/2003/0301/p979.html

Thank you Nervous.

[chefaid90]

but could it cause all of these symptoms
Head-
Blurry vision need glasses but cant wear them do to my eyes always seem to be changing in amount of blurriness and vision capabilities this has gotten progressively worse.
Jaw pain feeling of muscle spasms in my jaw 2-4 times a month
I get eye twitches that can last several hours at least 2-4 times a month
Constant ringing in my ears can get loud enough that its painful
Hearing loss- esp with being able to process and hear what words are being said
Feeling of being off balance and dizzy
brain feels foggy and I am extremely forgetful
constant fatigue and rest and sleep dont help
talking is frustrating as I cant get the words out its almost like I start stuttering with trying to get the word out that I want to say or i combine words like i want to say cat dog and it comes out as dat cog.

Body-
Intense burning sensation in neck and shoulder and back- daily
Muscles in back are progressively being pulled tight started as lower back now has gone up my back to almost my neck area, becomes worse the longer im on my feet
Urinary incontiness (sp)

Arms-
hands go numb and cramp- daily
pins and needle feeling when I use them for normal everyday things-daily
burning sensation in arms-daily
getting harder to drive cook and write as they go numb, pins and needle feelings with small usuage. cant peel more than 3 potatoes without it starting and can only drive a few miles before the feelings start.

Legs-
pins and needles when i walk or stand to much ( cant get through a grocery store or walk more than 2-3 blocks before it starts then progresses to numbness and extreme fatigue which causes me to have to stop)
have lost feeling in legs causing me to fall 5 times in the last 4 months
Feelings of creepy crawlies on my which causes me to scratch and scratch several times weekly
Loss of balance from walking- almost daily

I have begun to not want to go out any where cause of the fatigue numbness and pins and needles feeeling. Doing normal everyday things are getting harder and harder to do. when I go to the grocery store i am either forced to do only a little shopping or to get a scooter as i can not make it through the store. i have since stopped taking the kids out as i can not do the walking without extreme fatigue and the pain.

If I keep progressing at the rate I am going in less than 5 years I will be in a wheel chair. I went from being able to do anything I wanted to not being able to make it through the grocery store without having to get a scooter to make it through.

My emg was normal
My blood tests were all normal
b12 was checked it was 330
no lyme was checked
Mri my neuro said was clean but report showed incedental nerve root sheath cysts not big enough to measure.

My neuro believes all my problems arise from low b12 level even though it is in normal range. she is sending me to a neuro opthomologist for my eye problems and told me to take some b12 supplements and come back in 2 months.

My family has a history of alot of medical problems my mom has metabolic myopathy 3 aunts have ms.

I have been dx'ed with
6th nerve palsy
idiopathic periphial neuropathy
muscle weakness
skin sensation disturbance
visual loss
that is all i can remember right now.

[mrsD]

Yes it is possible. A blood test is only a window of information for that one day.

If you had dropped from a higher value and are on the way down further...it will not show that.

The body tends to react severely to "drops" depending on how high it was before.

Glucose is the same way. If a person drops 50pts... from 150 to 100 in minutes...they will feel it differently than if the drop is
gradual over hours/days.

I think B12 is the same. Dr. Snow...in the article I quoted on post #70 believes there are people testing in the 400 range who still need higher levels. take a look at his paper...and he is the expert.

You may also have something else going on.... as well.

For example, muscle issues, cramping,stiffness may reflect low magnesium levels. This can be corrected easily too.

Take the methyl form of B12 (the active form) orally 5mg a day on an empty stomach. In 3 months you should test over 1000. There may be some changes for you in those 3 months. Most methylcobalamin is available online at Amazon, iherb.com, Puritan's pride and Swanson's. Using this form, at pennies a day will show within 3months if this is a problem for you.
Take on empty stomach only. That is the only way to get proper absorption.

The urinary incontinence suggests some spinal thing. So keep an eye on that.

If you read the posts on this thread you will understand more.
You just have to do this homework, to be your own advocate.

[NeuroLogic]

I read: "B12 or methylcobalamin can raise body temperature in a high dose."

What would be considered high?

I also read yesterday that a doctor who lived to 108 advised his patients with cold hands and feet to take B12.

Last night I woke up and took a B12 (sublingual), because it's very difficult to take on an empty stomach at other times during the day.

Later I woke up feeling more hot than usual.

As you may recall I've had problems sleeping because I don't sweat from the peripheral neuropathy, so I overheat.

This morning after a hot Mg bath my core temperature was 97.7F. I don't remember the last time it was this high. (It's usually 96 something or low 97s after a hot bath.)

Not sure if B12 is involved...

[mrsD]

There is a book from the 1990's that discusses this.

http://books.google.com/books?id=YLE...rature&f=false

It says that high dose INJECTIONS demonstrate changes in body temperature, measured rectally.

Methyl B12 is the cofactor for melatonin synthesis, and therefore will be a factor in normalizing circadian rhythms that are disturbed. It is mentioned in studies on sleep issues, and circadian rhythm normalization. Body temperature is included in that I would think.

The daily use of B12 orally is not really "high dose" biologically.
The dose is high in the tablets themselves, but by no means is all of that absorbed, as it would be via injection routes.

[deb54]

Hi, new to posting, but at my wit's end. I am severely b12 deficient and can't seem to tolerate the side effects of treatment. I've had several small bowel surgeries, am very reactive, any change in my diet or treatment plan for my immune disorders are always a disaster. For example: tooth blew apart during an MRI. EMG resulted in extreme lymph node swelling, dosing methylcobalamin resulted in higher BP, rapid heart rate, chronic cough and finally..one breast became swollen as well as the lymph nodes. I'm 57, have psoriasis and psoriatic arthritis, multiple food and chemical allergies/sensitivies. After my last bowel resection, these allergies seemed to go away...until starting the b12 sublinqual.

I started on 1000mcg of Pure Encapsulations methylcobalamin. Results were immediate, eyesight cleared, 4 yrs of neck pain, gone...I could move. My memory began to clear and I was nolonger apathetic. With the exception of depression, I had every symptom on any list. I was never tested until I noticed not eating GrapeNuts made me feel worse than ever. I brought this to my nurse prac's attention...tested my b12, which was 200. Started on suppliments without the other tests. Nurse prac didn't know about them or the importance of these tests. We assume I don't absorb much. I've lived most of my life w/out any source other than GrapeNuts cerial.

Other adverse reactions: extreme depression of which I'd never had before, burning urination, swollen hands, legs, (not an illusion, I measured. I only wiegh 100 lbs, easy to tell.) nightmares, panic attacks, weight gain, fibroid formation. psoriasis worsened, chest pain, breathing problems.

Positive reactions, memory returning, neck pain gone, I can move again, strength returned.

Questions for any of you on this board..and thank you for reading this far...

Has anyone had severe, odd reactions to b12 suppliments? What were they and how did you solve the problem? Have you ever heard of anyone with these sort of problems? What kind of physician should I see next? I've seen my rheum, 2 internists, nurse pracs, nuerologist, and allergist. I haven't seen my nurtritionist, nor have I seen a gastro. Injections are not an option, pure methylcobalamin without preservatives or additives results in swelling of tongue throat amd mouth.

This is serious, I have to have the stuff, can't take an anti-allergen, not even epi...currently dosing 25mcg twice daily for 3 days, then 1 dose 25mcg, then skip a day. The skipped day is misery. any ideas???

deb...