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05-13-2009, 02:24 PM
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Junior Member
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My skin punches were done on my left foot and left upper thigh. At the time of my biopsy, I only had symptoms in the lower leg and foot. From my report:
The normative values for epidermal nerve fiber [ENF] density are evaluated by counting 3-6 different sections of each specimen and expressed as a number per millimeter length of epidermis. Any value that is equal to the fifth percentile or less is considered to be significantly reduced nerve fiber density, consistent with small fiber neuropathy. The fifth percentile value for the thigh is 8.0 millimeter. The fifth percentile value for the distal leg is 5.0 per millimeter. Lt. Thigh, Epidermal Nerve Fiber Density: Skin with normal epidermal nerve fiber density. Result value = 9.26 Lt Foot: There are only traces left of the subepidermal neural plexis in the biopsy from the foot observed with the anti-PGP 9.5 immunohistochemical stain. Result value = 0.07 |
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05-14-2009, 06:23 AM
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#2 | ||
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Magnate
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--even though Ides' intraepidermal nerve fiber density values for the thigh are within the "normal" parameters as set up by this protocol (the MacArthur protocol, after the person who originally designed it at Johns Hopkins), they're still in the very low part of "normal", since 8.0 is the fifth percentile.
The results are certainly consistent with a length-dependent small-fiber neuropathy. |
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My biopsy results
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