I am working up to 120 of cymbalta. I am very thin though and they suggested it still. I do know I was on 60 for awhile and it did nothing for my pain and they said it was more the depression dose. Mrs D I remeber yous aying that and I had high liver in the past which finally is in the normal range so am going to ask next time but my blood pressure is low. I have the temp issue too to cold. You said the aching and I do too but was wondering do you have cramping? I often feel so cramped and my neuro said that is like a muscle spasm and I have started klonopin. I never heard of Cymbalta though being for inflammation not to say it is not. Do you take omegas?