I am working up to 120 of cymbalta. I am very thin though and they suggested it still. I do know I was on 60 for awhile and it did nothing for my pain and they said it was more the depression dose. Mrs D I remeber yous aying that and I had high liver in the past which finally is in the normal range so am going to ask next time but my blood pressure is low. I have the temp issue too to cold. You said the aching and I do too but was wondering do you have cramping? I often feel so cramped and my neuro said that is like a muscle spasm and I have started klonopin. I never heard of Cymbalta though being for inflammation not to say it is not. Do you take omegas?

In rats....this is one study on this subject:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

This study does not include both used together ...also in rats:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

This paper discusses different types of pain in RATS, and
antidepressants:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

There are only these 3 papers on PubMed when using the keyword search "duloxetine inflammation"

There are NONE for humans.

Grrrhhh, if a doctor told me there is no need for me to be as uncomfortable as I am, I think I would want to slap them (non-violently of course!)

Goodness, when it comes to feeling uncomfortable - geesh you are going to be the expert on that!!!! Seems to me that PN is not remotely logical in terms of how much pain someone is in - and if it hurts, it hurts,

Actually I tend to have 6 monthly or yearly reviews with my neuro, and my GP handles everything else - for anything urgent I have to go to neuro daystay at the hospital which is a pain. But, if I wanted to schedule more regular neuro appointments then I could ....

Do you have a good GP who can handle things meanwhile? That makes all the difference in the world ....

feel better soon
raglet