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Magnate
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--is different from "normal" or nociceptive pain in that the pain is not a response to other damaged tissue, but is due to damage of dysfunction to the nerves themselves. Abnormal firing patterns caused by demyelination or axonal damage can well be interpreted as pain by the brain--or as numbness, tingling, or a host of other weird sensations (parastheses) depending on the location and severity of the damage.
Neuropathic pain can be generated either through peripheral nerve dysfunction of through brain/spinal cord dysfunction (such as in multiple sclerosis); it's often difficult to distinguish the source of the pain unless there's extensive investigation, as they can "feel" the same. Moreover, peripheral nerve dysfuction is NOT necessarily characterized by disruption in reflexes--again, it depends on where the damage is. Many small-fiber syndromes leave reflexes intact (reflexes involve larger fibers). And certainly brain/spinal cord dysfunction can cause reflex disruption (or not, again based on location). |
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