And yes, anyone depleting CoQ-10 would do wisely to take some.
Watch for any improvements to gauge if it is helping. The most likely obvious thing with CoQ-10 is less fatigue and more stamina as it helps with the heart and muscle energy requirements.
Some people with Parkinson's use very high dose CoQ-10 to help with tremors because those cells may have damaged mitochondria in the brain. Each person will have different responses depending on their own weakness/error in chemstry.

This is why I don't like big combo mixture products for PN.
When several are mixed together in one pill...you cannot tailor your doses to what YOU need. Because all of us are different in what we need.

Dear Mrs. D,
I will start the Benfotiamine today.
I will also order online the R-Lipoic and Acetyl L-Carnitine this week.

Assuming I have a reactive hypoglycemia, are these supplements safe to take?

Can the Acetyl L-Carnitine be taken together with my other supplements?

You mentioned in one of your posts in this thread that our body makes CoQ10and if no improvement is "felt" after so many months, it is safe to discontinue. But if one would want to continue using it, is it safe to use for a longer period of time just like Vit E and C?

What about Benfotiamine, R-Lipoic and Acetyl L-Carnitine, can they also be taken for a long period of time?

Thank you so much Mrs. D!

As far as your R-lipoic goes.... you should be able to take 100mg a day. If you have side effects, you can do it every other day.
But if you just make sure you have a snack in the morning and one before dinner, and one before bedtime, say a small snack.
Some cheese, 1/2 of a protein bar (there are new ones available from Nature Valley now in most stores), or some other protein thing, like Kefir or yogurt, you won't get low. Watch your sugar intake and you'll be less likely to get low. The new Chobani yogurt is quite high in protein for example. You got low on the glucose drink and regular food is much different.

Benfotiamine is safe by all accounts in the studies. I wouldn't worry about it. Same with the acetyl Carnitine. The biggest issue for most, is the cost. You should feel more energy on them all, and have more stamina. I have seen carnitine papers for both hypo and hyper thyroid states so I wouldn't worry about it either.
500mg a day is a good start for the carnitine.

Mrs. D, what possible side effect/s is expected from R-lipoic?

Do you recommend Doctor's Best for the R-Lipoic?
Its only Jarrow which has 500mg for Acetyl L-Carnitine, should I get this?

Thank you. You are an angel!

Side effects from R-lipoic may be irritability or anxiety. Not all of our posters here get this. But I did and a few others.

Take the R-lipoic on an empty stomach for best absorption.

You may not see anything at all.

Acetyl Carnitine comes in 250mg also...from Puritan's pride.
The carnitine allows your body to metabolize fatty acids instead of glucose when glucose is low. So it might really give you a boost.

But Carnitine really only has GI symptoms in excess of 10 grams a day! We don't use anything near that dose at all!
It is really easy to tolerate. It just costs alot of money, like the CoQ-10 does.

I just bought Qunol (ubiquinol) at Costco this week, on a big sale. I've just finished 300mg CoQ-10 I found in my packing box for upNorth! I bought this last summer at SAMs club. I am just starting to see some effects (less need for naps for example) after 60 caps! one a day.

I'll do the Qunol and see if there is any change. I think CoQ-10 is a slow slow response depending on the quality of the product you choose.

Supplements that affect metabolism, work very slowly... you have to be observant to really feel them sometimes.

I have recently joined this forum, thanks so much for your info Mrs. D. I have been researching supplements that help in methyl conversion that may assist in regeneration of nerves damaged by idiopathic polyneuropathy in my feet. Especially interested in your opinion of TMG, DMG and a supplement called Phosphatidylserine. Also have found warming my feet while taking a sublingual B-12 5mg seems to help speed the nerve recovery, which is still very slow, but is progerssing. Would heating pads and tens units help my feet with more circulation of these supplements? How about L Arginine Gel? Should I be walking for an hour a day like I used to before this affliction hit me, or would the walking make it worse. I am using all the supplements to rebuild mitochondria, (CO Q10. Benfotiamine, Biotin, ALA, Acetyl-L-Carnitine, Magnesium. Any suggestions you could provide to speed up my foot polyneuropathy reversal would really be appreciated. BTW, my neurologist said my condition was irreversible, and likely progress to more pain as I age. I'm 60 years old. I am taking 600 mg of gabapentin per day, down from the 1500 mg I was taking several months ago. Thanks much for all your help.

Welcome to NeuroTalk:

If you use heat TOO much...you may make the nerves hurt more.
Some is good... too much is not good.

Have you had testing for MGUS or other Ig proteins? This may make your circulation slower.

Do you smoke? This can reduce circulation to the legs and feet.

You could try the arginine gel. It may help. But I would encourage you to find some more answers eventually.

You suggest that I take 250mg instead of 500mg for the Acetyl L Carnitine?

Thanks much Mrs D. I do not smoke, I have been tested for protein via electrophoresis, all is well there. No test for Ig protein that I can see on my labs.

Would walking help my foot neuropathy?
Thanks much.

You could.... start at 250mg twice a day.

This is because acetyl carnitine is not absorbed well, so divided doses give you MORE.

It is a fine point, but if you do well on less, then that is something you need to know.