Mrs. D - Thank you for sending me the link to all the posts about supplements for PN and the links to articles about PN (causes, diagnosis, and treatments). All very helpful!!!

I know all supplements/treatments won't work for all types of PN. What do you know about PN caused by autoimmune disorder, like Sjogren's Syndrome, or caused by autonomic nervous system dysfunction. If PN has one of those causes, will supplementation still be effective? Or is PN that is caused by autoimmune or autonomic problems less responsive to supplementation therapy? I can't remember where I got this sense, but I remember seeing this somewhere. Hopefully I am wrong.

Thank you.

There is a connection to immune dysfunctions and low Vit D.

So getting that tested is important.

Also autoimmune issues have inflammation present, so using things that dampen inflammation would be helpful.
Fish oil 3 a day (or Krill oil, 2 or 3 a day)
antioxidants, like grapeseed extract, enhanced absorption curcumin, and/or astaxanthin may help. I use 200mg of grapeseed extract for my arthritis and seasonal allergies.

Sometimes there are more than one thing going on. People can have multiple problems.

If you are having fatigue, then supplements that improve energy in the mitochondria may help. R-lipoic acid, acetyl carnitine, and/or the ribose may help that.

Inflammation can be fueled by diet and food choices. So eating an anti-inflammatory diet may help.
You can look up inflammatory indexes on this site of your food:
http://nutritiondata.self.com/

Getting rid of sugars in all forms is a good first step. Increasing insulin in the body increases inflammatory actions. So eating a low carb, high protein, moderate good fats, diet is helpful.

A study reported in yesterday's New York Times stated that high levels of CoQ10 correlated with higher incidents of certain very aggressive forms of prostate cancer. There was also something about high levels of omega-3.

Anyone else see this in the Times?

This is the article I believe:
http://www.nytimes.com/2011/05/03/he...er=rss&emc=rss

No where does it state what high levels were.

How much fish oil had to consumed to give those "high" levels.

With nutrient research there is typically a back and forth of positive and negative outcomes. Some depend on who does the research and how the study participants were chosen.

I'll see later if I can find the study on PubMed... can't do it right this minute...but later I will try.

Quickly I found this that quotes a Harvard study showing the reverse:
http://www.huffingtonpost.com/craig-..._b_832661.html

It seems like we often find ourselves in this position. It's hard to make good decisions when the arguments can go either way.

Personally, I am backing off of my supplements routine this week. The reason is that I tend to go overboard and pile everything on. I think that can be hard on my body. So, I'm adding things back a little at a time. I don't know if I will "feel" when I have reached the correct dose of something like Vitamin D, but I will see how things go.

That is a good idea.

Keep the B12 and Vit D (were you tested? so you know how much to take?) If you don't want the D3 supplement, get some sun each day.

Keep the Lysine (to see if you have viral problems). And the acetyl carnitine (mito damage).
These major ones hit the big areas that are most commonly damaged or having problems.

We also have to understand "high".... the essential fat in flax oil, has to be consumed in some quantity daily. We cannot live without it. So what is "high" exactly in the studies? 5 grams? 10 grams? One capsule of the oil is typically 1 gram with about 40% ALA (alpha linolenic acid) in it. I don't think that is "high" for anyone who has to be eating it and is not typically. So understanding doses is also important.

My Vitamin D was 48 or 43. I didn't get my B12 tested.

Funny you should mention the Lysine. As soon as I stopped all my supplements (except my multiple vitamin), I woke up with an entirely new foot pain, so I have been adding back 500 mg per day of Lysine. My burning sensation continues to spread, with or without supplements. I don't yet have the kind of pain that some of our members have, but I fear where this is headed.

Hi All,

I have suspected PN for the last two months or so. Symptoms are not severe, but occur on a regular basis in the evenings/nighttime(tingling, pins and needles, sharp random shooting pains).

Brief medical history. I have hypothyroidism and taking 0.05 levothyroxine for the last 5-6 years.

In 2016 was diagnoted with gout and take 200mg allopurinol daily for hyperurecimia. Can allopurinol cause neuropathy? I saw some google articles on it.

I am taking the folowing supplements on a daily basis
1) R - Alpha Lipoic Acid (600mg/day)
2) Dr's Best Benfotiamine (600mg/day)
3) Milk Thistle (500mg/day)
4) Methyl B12 (1000 mcg/day)
5) Curcumin (500mg/day)

Anything to add to the list/subtract from the list?

PS : Since levothyroxine interferes with other meds /vitamin , particulalrly R-ALA , i take it four hours before/after any other vits /meds.


Thanks and much appreciated

I believe that it was in this thread that someone said they were taking 600 mg of benfotiamine. I'd be grateful for guidance and opinions regarding dose size for benfotiamine. I'm taking 300 mg now.

I take 250mg of the Mega Benfotiamine by Life Extension. It was added to my ALA and other supplements a couple of months ago. The rate of nerve healing went way up. My feet are almost healed now.

My Autonomic neuropathy was only noticed in my feet as far as what I could feel but with my POTS, it is all over of course. My OI (POTS) is so much better now also. It is very exciting. I am thankful for supplements that heal.