Sorry to hear this MG. Hope something helps. I noticed no difference with daosin I bought, but I still have no clue why the blue cheese affected me so badly. I'll have to try it again while I'm in a lull.

I don't want to think about how much money I've spent on supplements through all this, but I keep trying. Thankfully I just got a new job that will help fund my experimentation better.

My face is so scary today that I worked from home. This is awful!!!!!

And congrats on the new job!

Another good link about Histamine Intolerance.
http://www.amymyersmd.com/2013/10/ev...e-intolerance/

Oddly enough it was my birthday the other day and my wife said, I don't care what this is gonna do to your nerves have a small scoop of Ice Cream tonight! You have to at least have something bad on your birthday! So, I did. I also decided to take a benadryl while no one was looking in anticipation of what was coming after reading these studies posted here. Normally Ice Cream would've had me up all night in buzzing burning pain (and no, i am not a diabetic). After the Benadryl i had almost no pain that night. I was of course tired as heck! I apted to not take my nightly gabapentin because the benadryl basically seemed to take care of the pain and give me the same groggy reaction. I can't see taking something like Benadryl on a daily basis (especially seeing it can cause low DAO), but in my case it definitely supports the connection of histamine and nerve pain/inflammation.

Five years later, an allergist/immunologist is looking at my histamine levels as my potential problem. Sigh.

I want to post this information here in case it should ever help anyone.

From Histamine - Wikipedia

"Once formed, histamine is either stored or rapidly inactivated by its primary degradative enzymes, histamine-N-methyltransferase(HNMT) or diamine oxidase(DAO). In the central nervous system, histamine released into the synapses is primarily broken down by histamine-N-methyltransferase, while in other tissues both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2, further process the immediate metabolites of histamine for excretion or recycling."

I believe low levels of HNMT is a contributing factor in my neuropathy. DAO supplements don't appear to help at all. These two SNPs on the HNMT gene have been documented as resulting in reduced levels of HNMT, and thus a reduced ability of breaking down of histamine that could impact proper functioning of the CNS:

rs1050891 - A/A is normal, I'm A/G
rs11558538 - CC is normal, I'm C/T (C314T Thr105Ile)

Both are tested on 23andme, although the second isn't available by SNP name. (Ping me for more information.)

The immunologist who diagnosed currently has me on Zyrtec once a day and 40 mg of famotidine (Pepcid AC) twice a day to try to get my histamine levels down. My plasma histamine level was high in the blood test he ran.

I'm also on a low histamine diet which has helped bring them down as well. one or both actions has pulled me out of a terrible flare I was in caused by three consectutive days on high histamine food consumption. It was so bad that I actually did have a classic allergic reaction. That's what caused me to make an appointment with an allergist/immunologist. I knew it had to be a clue.

I was very fortunate that this doc whose office is two miles from my house is well-versed in Histamine Intolerance and Mast Cell Activiation problems. Not all are.

I continue to learn about my condition and determine the "triggers" that cause me to flare and turn into a ball of fire.

Quercetin with bromelain appears to be one of the most helpful supplements as it's a natural antihistamine. I'm also taking palmitoylethanolamide (PEA) with luteolin for its mast cell stabilization properties.

(PDF) New Insights in Mast Cell Modulation by Palmitoylethanolamide

Overall, I'm feeling much better and am doing a decent job of keeping the flares to a minimum. It's a learning process, though, as you have to figure out your triggers, and they're not always consistent. For example, you can make a recipe one day that doesn't affect you, but the next time, it does. The freshness of the meat comes into play, and that can obviously a big unknown.

I so wish MrsD were still around. I think of her often and hope she's doing ok.