http://www.healthline.com/health-new...ymptoms-030915

Vesicare is safe

Interesting. There are doctors out there who say Myelin can't be regrown at all. Don't you love them. So hopeful and optimistic. I know there was a study years ago that said even Topamax helped regrow mylein. Topamax supposedly is just brutal to take becuase if the side effects.

I wonder though if the brain related damaged mylein is different than the small fiber related mylein. I don't see a them saying it applies to all mylein damage just the brain related. Maybe someone on here knows what's up with that. Of course its mice so, not exactly a confirmed cure. Would need clinical studies. but liek I say why is it reason to panic when mice get cancer from things like aspartame, but when we see something hopeful in mice we poo poo it and say, its just mice doesnt mean much.

Judgoing by the comments section below it doesnt look very hopeful but those are MS patients, not SFN sufferers.

This is from 2003, it makes Topamax sound like a miracle cure. But, from what i have seen the side effects from it are pretty harsh.

"Topiramate improves both symptoms and objective measurements of peripheral neuropathy while also lowering levels of total cholesterol, blood glucose, and blood pressure and promoting significant weight loss," Dr. Vinik said.

Because previous trials had shown that high starting doses of topiramate can be toxic, the patients were administered 25 mg/day, titrated over 42 days to the maximum tolerated dose or 100 mg/day. The patients received the anticonvulsant for 84 more days. By the end of trial, dendrite length and peroneal nerve amplitude had increased, and total neuropathy scores had decreased from 14 to 11.8, Dr. Vinik reported. More important, "intra-epidermal nerve fibers actually grew back," he said. "That was the most dramatic observation."

http://www.medscape.com/viewarticle/457287

Anticonvulsant in general can help pain from neuropathy because it inhibits neuro firing. But if u inhibits normal firing. What do you expect as a side effect, and it would be pretty harsh. Gabapentin comes out the top in terms of least side effect for neuropathy hence prescriber use it often, until now the updated guideline recommends antidepressant more. But none of these really help with nerve regeneration

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I just happy I took both Sphingolin and Inosine for the 3 months I did as the BURN is gone from my thigh. Every now and then I may get a tingle but nothing like it was for 5 yrs after hip replacement nerve damage. I had no fears of trying it and glad I took the chance. So many talked about the dangers but I didn't feel that.

Now I'm going to use a Tens unit and see if the numb thigh could be helped...could the nerves be somewhat restored with a Tens.

From what I could find on animal studies (mice), TENS Units actually damage crushed sciatic nerves, especially at high frequencies.

Dave.

TENs is for blocking pain signals. There is little evidence that any healing is promoted. (this is what my PT said when I had my therapy.)

IFc is used (sometimes in conjunction with ultrasound) to actually promote healing. This treatment at my PT reduced my severe tendon injury in about 3 treatments. The pain remaining was bearable. I was pretty impressed.

Anyone else have tried this and have any feedback?