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Originally Posted by Mpiazza000
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This is from 2003, it makes Topamax sound like a miracle cure. But, from what i have seen the side effects from it are pretty harsh.
"Topiramate improves both symptoms and objective measurements of peripheral neuropathy while also lowering levels of total cholesterol, blood glucose, and blood pressure and promoting significant weight loss," Dr. Vinik said.
Because previous trials had shown that high starting doses of topiramate can be toxic, the patients were administered 25 mg/day, titrated over 42 days to the maximum tolerated dose or 100 mg/day. The patients received the anticonvulsant for 84 more days. By the end of trial, dendrite length and peroneal nerve amplitude had increased, and total neuropathy scores had decreased from 14 to 11.8, Dr. Vinik reported. More important, "intra-epidermal nerve fibers actually grew back," he said. "That was the most dramatic observation."
http://www.medscape.com/viewarticle/457287
08-19-2015, 04:46 PM
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