Pathophysiology of the systemic inflammatory response after major accidental trauma

http://www.sjtrem.com/content/17/1/43

"Also, the ability of the monocytes to produce cytokines is impaired following major trauma. This has been shown in vitro where monocytes from trauma patients were stimulated and afterwards showed a reduced production of cytokines. Thus, following major accidental trauma the monocytes do not show a biphasic pattern. In contrast, the function of monocytes is continuously decreased."

S.

Hi S,

Very interesting article. So the underlying conclusion of this paper is to wait 3 weeks for surgery when "major trauma" had incurred? I think your last link was "The Biochemical origin of Pain" or something (major hit with some of my friends). So combining the thoughts of these two papers you think there could be an increased incidence of CRPS by performing surgery within 3 weeks of major trauma?

BTW, what was the criteria or definition for "major trauma," do you suppose?

Yes I think that there is a period of neuro inflammation after any trauma let alone major trama.. And in that time frame we are very suceptable to things like RSD as well as other illnesses related to neurgenic inflammation.. I cant prove RSD is in that category but it makes so much sense.. same with the spreading of RSD it is I believe through neurogenic inflamitory process that this happens to us.

I planned on posting this on a new post and I will anyway but have a look at this.. I had a hard time hunting it down lol.

Does neuroinflammation fan the flame in neurodegenerative diseases?
http://www.molecularneurodegeneratio...-1326-4-47.pdf