Sorry to hear about your wife's situation. I know how rough it can be. Of what I know through my own experience is that there's no cure as of now and we mostly are managing the pain with treatments and meds. Nobody seems to have a handle on why some people get it and some don't. Just how we get it. In the same fashion we don't know how to get rid of it completely but only how to treat it.
Every doctor that examines me comes to the same conclusion. 'The only thing that they can do at this point is manage my pain with meds'.
Good luck to you both....