Thanks so much for you response back Sandy! Unfortunately I have not been able to tolerate using my leg at all without the use of medications since I crushed my knee in 07 and they've always only just took the edge off the pain...even back then. I was hoping that the SCS would allow me to fully wean from opana and norco but cutting them back has only been possible. The pain has never been gone even for a minute except the day I tried the Ketamine though! AMAZING! That makes alot sense as what you're saying about competing for receptors...I get it. So, maybe I will ask my pain doc if I should skip the pain meds before my next infusion. I was instructed to take all meds the last time. I also wonder if the SCS should be turned off too? Would that impact results as well or no? If I get the same results with the next infusion or I get good pain relief but it doesn't last long, I have another option with a RSD specialist to do a 5 day infusion but he is over 3 hrs from home and must make arrangements to stay there for 5 days. Today, I did read that with RSD, when you get a positive result with this med, the more the better it seems to get the longer lasting *remission* or pain relief states. The goal is to trick your brain into thinking the pain is gone. Might be awhile before I can do the 5 day back to back infusion but I would definitely consider it! It is truly amazing what it is doing for you too!! I am so very glad I made that appt and took that 2nd opinion with the RSD specialist...he is the one who suggested trying this too! Hopefully the next time the nausea won't be as bad either..I apparently needed some Zofran according to the nurse. Does that get better over time as well? Thanks again Sandy!! I'm happy it's helping you so much too!!! xoxo