The cause of CRPS is now much closer to being understood.. research has been pointing in this direction for quite some time now but scientists have recently injected antibody serum from CRPS patients into rodents who then developed CRPS symptoms after injury, the rodents who were given control/normal antibody serum did not develop CRPS symptoms after injury..
This is HUGE for CRPS research.. and for us because it can possibly be much more treatable now, even for chronic cases. Copied from RSD/CRPS research and developement on Facebook .
Doesn't seem to stim from the brain as once thought!!!!! Awesome news. I am pumped.
Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.
Pinpoint the cause
Dr Goebel said: “It’s quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure.”
The project was subsidised by the European Union and co-financed by the European Social Fund. 7, the Pain Relief Foundation, Liverpool, UK,

In mice injected with the antibodies from CRPS sufferers, there was significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient’s limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P.
Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.