[QUOTE=Littlepaw;1245286]I personally haven't seen mention of bisphophonates for late stage recalcitrant CRPS.

Here is an article summary by M. Varenna who is responsible for the Italian research that brought us neridronate. Varenna states that in most studies these drugs are useful early on and actually may not work as well in long standing disease. Neridronate is currently in US safety trials.

Bisphosphonates in Complex Regional Pain syndrome type I: how do they work? - Abstract - Europe PMC



Littlepaw,
This is my recollection as well. I was right at a year when I was diagnosed and it was clear from my research that I needed to get the bisphosphonate treatment then or never. I actually investigated going to Italy, but the truth was I could not do it. I couldn't make the 45 minute drive to RI to see Dr.Chopra, never mind an international journey.