This is very interesting and includes other inflamitory conditions..
I can't help but wonder at the conectivity of spread of RSD and the spread of inflamation somehow..

http://www.rsds.org/electronic%20ale...22008_138.html

There is alot more to this artical, any thoughts?

Dear Sandra -

I thought it was an interesting article and one that ties in well to another recent piece I just attached to a posting under the "Inflamation, any tips to reduce" thread:

. . . there's been recent work done that shows the mechanism of "Association of catastrophizing with interleukin-6 responses to acute pain," Robert R. Edwards at al, Pain epub 2008.07.24, a copy of which is attached for anyone who's interested. It's a very interesting article that can probably be read on a number of levels, but it basically demonstrates that “catastrophizing” produces inflammatory cytokines in and of itself. . . ."

http://neurotalk.psychcentral.com/thread55412.html

I have a pdf copy of the Fiorentino article to which you refer and will be happy to email it to anyone who drops me their email in a PM. (It's too large to attach here.)

What's going on here is that people have for a long time been saying "I see cytokines, therefore RSD must be inflammatory in origin." I know that I took myself out to Johns Hopkins a couple of years ago and sought to get in on a trial of an anti IL-6 drug: fortunately I was refused. The message here is that a number of folks, including perhaps even Anna Louse Oaklander, M.D., may have gotten the causality on this thing backwards. See, "Editorial: RSD/CRPS: The end of the beginning," Pain, epub 2008.08.06, a copy of which is attached.

Mike

Attached Files

RSD-CRPS The end of the beginning [Oaklander editorial].pdf (58.3 KB, 2430 views)