Although cytokine production by activated glia precedes the apoptotic loss of hippocampal neurons in brains from scrapie-infected mice (47), the experiments presented here suggest that TNF-α and IL-6 alone do not play a critical role in the development of pathology in the CNS. Therefore, the apparent resistance of TNF-α−/− mice to i.p. challenge with scrapie could not be attributed to a role of TNF-α in the development of pathology in the CNS. Our experiments strongly suggest that the effects of TNF-α operate at a peripheral stage, prior to neuroinvasion.
http://www.pubmedcentral.nih.gov/art...i?artid=111835

http://www.microbiologybytes.com/virology/Prions.html

Hi Mates,

Even though I am in the States now, I still am English.
http://www.protomag.com/assets/in-pursuit-of-prions

Yes, I am 100% still out of pain. But I had to know why I got RSD, after my injury. The pain is just a SX of what what wrong with me. My nervious system was supposed to be protected, but it wasn't.

Much Love, Roz

Buckwheat,
I'm skimming what you have here, but is there any link between an increase in the incidence of RSD within populations most likely exposed to infectious prions (say, butchers or populations ingesting prion contaminated food)? Are there any autopsy findings indicating prion disease in those who have RSD as there are with CJD? Typically, these things are found and prion-related disease yields significant cognitive slowing over time which I haven't seen in the research with RSD, though I'm by no means any type of expert.
Lori Lee

Hi Lori Lee,

I hope these lines find you doing well. I am by no means saying I have this or anyone else. But in my case I have always known something broke the BBB.

The first 3 years I had just noticed the RSD in my PNS, a bit after the 3 year mark it went to my CNS. Around 5 years into RSD I noticed short term memory loss,with cognitive impairment as well. Maybe some others who have had RSD for over 5 years can share weather they have cognitive impairment, or short term memory loss??? I have lyme and Bartonella though, I also had to be treated for other parasite infections as well. Much Love, Roz

Hi Again,

No I could not find any autospy findings relating it to RSD thank goodness. But I could't find any relating it to Bartonella either.

I was raised pretty much a vegetarian, and still somewhat am. Hugs, Roz