I just saw this thread in the index...

As luck would have it, this article in a very recent Science News discusses mitochondrial damage as a source of chronic illness.

http://www.sciencenews.org/view/feat...ndria_Gone_Bad
This makes more sense to me because what is coming out of the new research is that ANTIBIOTICS and other drugs (like statins), can damage mitochondria. The autism community has some interesting new studies showing vaccines may do this and antibiotic treatment for ear infections or other things that happen to little kids, often precede the appearance of autism.
The mitochondria in our cells are basically similar and actually derived FROM bacteria. So agents that KILL bacteria, may kill our mitochondria too.

example:
http://www.autism.com/medical/resear...ntibiotics.htm

There already is a supplement made by Dr. Bruce Ames who studies mito deterioration as a cause of aging:
Juvenon
http://www.bruceames.org/

I think it is more likely that RSD is closer to mito damage than is to sarcoidosis. The treatment the Marshall Protocol uses is a angiotensin receptor antagonist like Benicar (also used to lower blood pressure). This protocol also requires very low intake of Vit D...and that alarms me since Vit D is showing anticancer, and antidepressant and many other positive effects for people. I have seen many fibro patients on this and another forum improve when Vit D levels were normalized from very low. This implies to me that using the Marshall Protocol for fibro would not be a good idea. This protocol remains very controversial among doctors still.

Please read the mito article at the beginning of this post, and look at the diagram included. It makes it easier to visualize how this chemistry works.

Dear Mrs. D,

Thanks so much for your knowledge. But don't you think a serious pathogen in the body can effect cell to cell signaling? Much Love, Roz

Yes, Roz. The cell to cell signals are mediated by Cytokines.
These are short range hormonelike substances.

Thromboxane initiates platelet actions during trauma.
Leukotrienes initiate the release of histamine from mast cells and signal the immune system to fight invaders.

There are families of these substances. PGE1s, PGE2s, PGE3s, etc. All with certain functions. The Series One type are for homeostatis, and the Series 2 type are mostly for inflammation
and response to trauma and stress, the Threes, are mixed.
There a just an amazing array of others.

The body favors PGE1s on a daily basis IF and only IF certain nutrients are available to make them. This is Omega-3 territory, alpha linolenic acid, from nuts and seeds..like flax.
The Omega-6 fats come from plants also, and favor making the PGE2s. When the diet is too low in Omega-3, then we don't do well...we get stuck in the inflammatory side and that causes inflammation, blood clots, allergies etc. So a balance is needed.

So far using DRUGS on this system has brought some failures.
Cox-2 inhibitors which block PGE2 inflammation and arthritis pain, fail and Vioxx actually killed people because one of the PGE2 cytokines is a vasodilating agent..the body uses in trauma (swelling), but also keeps our coronary heart arteries open. Singulair which blocks leukotrienes and reduces allergy, and asthma, will also fail to signal when bacteria get out of control in the lungs, and the result may be pneumonia and death. NSAIDs like ibuprofen work in the short term for swelling for pain, but if taken for over 6 wks in a row, they actually block healing PGE2s that we need for tissue repair.
(they are good and bad both).

In the end, it is balance we need. Our bodies will balance if we provide them with the proper nutrients. So far drugs for these systems have not worked very well.

Bacteria stimulate the release of many cytokines so our bodies will survive. Leukotrienes to motivate white cells, and PGE2s for swelling (increasing blood flow) of the area.

Dear Mrs. D,

I hope your day is so full of love because you are truly a blessings to soo many of us.
I just want to thank you from the bottom of my heart, for making the time to help us.

Much Love, Roz