OT - Valacyclovir/Valtrex
 

Off Topic FYI

This first one is a single case study but it is a very interesting article despite the limitations and the financial disclosures of the doctor.

Is Valacyclovir a Mood Stabilizer? Autism 3:118. doi:
Henderson TA (2013)
http://www.omicsgroup.org/journals/i....php?aid=19860

[open-access article distributed under the terms of the Creative Commons Attribution License]

Adv Mind Body Med. 2014 Winter;28(1):4-14.
Valacyclovir treatment of chronic fatigue in adolescents.
Henderson TA.
http://www.ncbi.nlm.nih.gov/pubmed/24445302

TBI - Adult onset Tics
 

http://www.ncbi.nlm.nih.gov/pubmed/21534741
Brain Inj. 2011;25(6):629-33. doi: 10.3109/02699052.2011.572944.
Tics after traumatic brain injury.
Ranjan N1, Nair KP, Romanoski C, Singh R, Venketswara G.
Abstract

http://informahealthcare.com/doi/abs...52.2011.572944
Full Text - Brain Injury, June 2011; 25(6): 629–633
Access has changed since this was first posted.
Full Text now pay per view.

_____________________

http://www.ncbi.nlm.nih.gov/pubmed/15867978
Rev Bras Psiquiatr. 2005 Mar;27(1):11-7. Epub 2005 Apr 18.
Secondary tics and tourettism.
Mejia NI1, Jankovic J.
Abstract

http://www.scielo.br/pdf/rbp/v27n1/23707.pdf
Revista Brasileira de Psiquiatria 2005;27:11–17
Secondary Tics and Tourettism
Nicte I Mejia, Joseph Jankovic
[head trauma]
Full Text

Motor excitability during movement preparation - TS
 

from Nov, 2013
Note small number of participants -
9 male. one female.
several with co-morbids.
some medicated. some not.
Nonetheless, it's an interesting study. :)

http://onlinelibrary.wiley.com/doi/1...jnp.12033/full
Motor excitability during movement preparation in Tourette syndrome
Amelia Draper, Lucinda Jude, Georgina M. Jackson and Stephen R. Jackson,
Article first published online: 28 NOV 2013
DOI: 10.1111/jnp.12033

http://psychcentral.com/news/2013/12...ome/63922.html
Scientists Tie Brain Mechanism To Tics in Tourette Syndrome

http://www.nottingham.ac.uk/news/pre...rome-tics.aspx
Researchers uncover mechanism controlling Tourette Syndrome tics
Click on - Click here for full story

TS, OCD - Differences in genetic architecture
 

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive
Disorder Reveals Differences in Genetic Architecture

from PLOS Genetics

Published: October 24, 2013
DOI: 10.1371/journal.pgen.1003864

Note: "This is an open-access article, free of all copyright"

Impaired activation of innate immune response -
 

http://informahealthcare.com/doi/abs...75.2014.907503

World J Biol Psychiatry. 2014 Jun 9:1-6. [Epub ahead of print]
Impaired activation of the innate immune response to bacterial challenge in Tourette syndrome.
Weidinger E, Krause D, Wildenauer A, Meyer S, Gruber R, Schwarz MJ, Müller N.

[I haven't read full text yet, only this abstract. $46US for 23hrs seemed a little steep]

Febrile convulsions increase risk of TS
 

http://www.seizure-journal.com/artic...138-1/abstract
Seizure - European Journal of Epilepsy
Febrile convulsions increase risk of Tourette syndrome
Yi-Fang Tu, Cheng-Li Lin, Chih-Hao Lin, Chao-Chin Huang, Fung-Chang Sung, Chia-Huang Kaoemail
Published Online: May 19, 2014

_______________

:confused:

Edited to add my comment -

I would wonder what type of illness or infection actually caused the febrile convulsions in the first place

Well I know strep infections can cause febrile convulsions as can other childhood viruses and bacterial infections....I wonder if what these researchers were finding was more related to PANS rather than TS?

Well that was sort of what I was thinking.
I'd love to read the full text when it is free, otherwise it is a bit of a puzzle.
My first thought was about the actual conditions that preceded the seizures in all of those patients to cause the fever in the first place.

Interesting too, is that there was another article on that same page suggesting that low iron and low serum ferritin may be risk factors for febrile seizures in children.

Association between iron status and febrile seizures in children
Soheila Zareifar, Hamid Reza Hosseinzadeh, Nader Cohan

http://neurotalk.psychcentral.com/post1041370-86.html
older articles re: ferritin, iron

anyway...

J Am Acad Child Adolesc Psychiatry. 2015 Jun
Epub 2015 Mar 17.

PubMed Abstract

Maternal history of autoimmune disease and later development of tourette syndrome in offspring.

Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB.

PLoS One. 2015 Mar 20;
10(3):e0120499. doi: 10.1371/journal.pone.0120499.
eCollection 2015.

PubMed Abstract

Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.

Harvey S. Singer , Adda Mascaro-Blanco, Kathy Alvarez, Christina Morris-Berry, Ivana Kawikova, Hilla Ben-Pazi,Carol B. Thompson, Syed F. Ali, Edward L. Kaplan, Madeleine W. Cunningham