Traumatic Brain Injury and Post Concussion Syndrome For traumatic brain injury (TBI) and post concussion syndrome (PCS).


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Old 03-07-2013, 04:52 PM #1
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Default Immune system possible culprit in sub concussive blows

For those who are interested:

http://medicalxpress.com/news/2013-0...-multiple.html

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Old 03-07-2013, 07:01 PM #2
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That is very interesting! Could help explain why some people are more susceptible than others. I've had a sepsis infection in the past and wonder if that left my brain barrier weakened for this?

Thanks for posting!

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I'm a 39 year old, female, accountant. On July 2, 2012 I crashed my bike at the end of a 65KM road ride. I was fine that day but woke up the next morning to my current world.

Ongoing symptoms include: dizziness, blurred vision, light and noise sensitivities, cognitive problems, uncontrollable emotions/depression/anxiety, headaches (but they're getting better), mental and physical fatigue, difficulty communicating and sleep disturbances.

Currently seeing a fabulous Neuro Psychologist and vestibular physiotherapist and hoping to soon see a neuro ophthalmologist. I am currently doing 20 minute stationary bike rides daily, 20 minutes of meditating, 15 minutes of Lumosity and lots of resting. I have not been able to work or drive since the accident.

The things that have helped me the most since the accident are vestibular therapy, gel eye drops (for blurred vision, sensitivity and dryness), amitriptyline (10mg), and meditating. I am finally starting to see some slight improvements and am hopeful!

My brain WANTS to heal itself... I just have to let it and stop trying to get better!
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Old 03-07-2013, 08:35 PM #3
Mark in Idaho Mark in Idaho is offline
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This is a very interesting study. It could be a part of why good brain nutrition is beneficial. The blood brain barrier is enhanced by folic acid and B-12. Also, myelin is helped by folic acid and B-12. A broad spectrum of B vitamins plus anti-oxidants helps the immune system function properly.

I wounder if they have looked into whether the glymph system plays a part in this issue. The glymph system has just recently been discovered. It is similar to the body's lymph system that drains away toxins and the waste generated when the immune system battles invaders. The glymph system surrounds the myelin that protects the nerve cells.

S100B has been researched for decades and has long been known as an indicator of brain struggles.

This autoimmune struggle could be made worse by vaccines. There is evidence that flu vaccines later in life are connected to dementia. The flu vaccine challenges the immune system often causing autoimmune responses that can challenge the brain. The more flu vaccines, the greater the chance of dementia.

It all seems connected.

I have a question for them. Why do I get immediate concussion symptoms from any jarring to my head ? This is sooner than an autoimmune response could cause.
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Old 03-08-2013, 06:35 AM #4
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Default Autoimmune connection

If anyone has more information on autoimmune connections I would be very interested. I have hashimotos, have had two five year battles with chronic idiopathic urticaria, the first time it also involved my muscles, markers for lupus....
I am wondering if this might be interfering with my healing.
Supplements have helped me a lot in the past. But I am already taking quite a few.
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Old 03-08-2013, 11:53 AM #5
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When I first started reading the article, I was struck by the phrase "this opens the door to investigating a vaccine or drug therapy to prevent head trauma." - and my first thoughts were - how is a vaccine or drug therapy going to prevent head trauma?

Then I watched the video, and aha.

Mark is correct, that S100B has been a long researched topic; however, sadly the only outcome so far has been that found here.
A possible tool to avoid doing a CT scan - which would then not find those little findings of super small bleeds or even those super suspicious boney skull injuries that I personally would not want missed.

Unless something newer in the literature has been found, I haven't read.
If they can work up a good ELISA/RAST/ANA,etc. - for tracking levels / reactivity it would be very useful for the development of therapies.

I hope they are successful in the future of working with the autoimmune factors side of the research; it would present better promise than what has come before.
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Current: Changes of more insomnia, new reviews with findings of more Depression, tremors, vertigo, tinnitus, loss of focus, fatigue; SSDI - accepted on Depression, Cognitive Deficits; Seizures ruled out, mTBI changes including cognitive slowing/lapses.
Medication update: Topamax 200mg twice daily it seems to minimize daily headaches to a 1-2/10 quality(I still know they are there); and acute headaches erupt without warnings.
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Old 03-08-2013, 07:54 PM #6
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Default Positive ANA Prior

I have have had an ANA test before and it has been positive. Does anyone know if it would be of much value to have the immunologist who did the testing pre-concussion to retest and see if there are any changes? I will probably have to beg to get workers comp to consider this.
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Old 03-09-2013, 08:27 AM #7
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As far as I am aware, they only have been developing the ELISA for S100B, so far, and its only in research - not sure if being put to use in general arena as yet.

I'm still digging in the reading to find more info.
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Current: Changes of more insomnia, new reviews with findings of more Depression, tremors, vertigo, tinnitus, loss of focus, fatigue; SSDI - accepted on Depression, Cognitive Deficits; Seizures ruled out, mTBI changes including cognitive slowing/lapses.
Medication update: Topamax 200mg twice daily it seems to minimize daily headaches to a 1-2/10 quality(I still know they are there); and acute headaches erupt without warnings.
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