I don't think that the SAMe fits in with all those others. B12 can raise your histamine levels. This relates to methylation and your homocysteine levels. The one that does not fit is the SAMe. Folic acid and b12 can raise histamine levels, but the SAMe would actually lower your histamine levels. So, that combo does not sound right to me.

Now, some people do have a problem with sulfur and can have problems with absorbing it through their GI tract. SAMe is a sulfur containing amino acid. The body gets rid of histamine through sulfation.

So, my guess is that it might be the SAMe that is causing the stomach aches. But that is the problem with taking several supplements at once, you can't tell what ones are working and what ones are causing a problem.

See, Buttons supplements include ALL but the SAMe. I don't understand why you were told to take SAMe.

Fatigue is the worst, I know. I would think that you may have some other deficiencies that you and your doctor are missing.

Can you tell us what doses you use for your supplements?

Do you use enteric coated SAMe? Enteric coated SAMe bypasses the
stomach... it doesn't dissolve until the intestines. (it is not stable in stomach
acid).

Except for the SAMe and B12, most other vitamins should be taken with food.
SAMe is best taken first thing in the morning at least one hour before food.

Sulfur is very plentiful in the diet, you would be eating far more sulfur containing amino acids daily than are in SAMe.. which BTW is a natural substance your body makes. (your body does not make, vitamins--they have to be taken separately.)

Mild gastric distress is sometimes reported by people beginning to take high dose SAMe, however, I have used it since 1999, and have never had an upset. Mild distress can be avoided with smaller doses in the beginning, and I think it has to do with the fillers in the tablets, not the SAMe itself.

Your neurological issues if B12 dependent can include neuropathies including the GI tract (gastroparesis). So you need to focus on getting that B12 level up. (When B12 is very low, it becomes low in the spinal cord as well).

Hi Mrs D,
Yes, I gathered the pills here, in addition to a weekly shot of 1000mcgs of b12
I was/am supposed to take:
Active B6 caps - 50mg
B1 - 100 mg
Folic Acid - 1 mg
Super comples Vitamin E 400 iu
and
SAM-e full potency 400 elemental- highest concentration 400mgs kept in fridge.

I always took the sam-e on an empty stomach, and the others through the day with food.
I had the feeling that a little explosion went off in my stomach, and it hurt for
about 40 seconds, then a minute would pass and the explosion would occur again over and over all day long.
I'm luckily not a stomach achey girl. I had my gall bladder removed long ago.
I have medullary sponge cysts both kidney and am a stone maker ugh.

I have a list of maybe nine different amino acids I am deficient in.
I googled them all, and each said it is very "rare" to be deficient in.
Is this another clue?
I am not vegetarian, I eat from all food groups. I didn't know neuropathies can occur in your digestive track. Interesting. thank you.

orthomolecular
thanks too, I thought the SAM-e helped to metabolize the b12 and make it available, or assisted in some way?

hi rose,
thanks to you too,
I have been sick for three years before this nuero picked up on the 220 b12 levels. He also knows my old neuro said "It's too early in the disease to do anything about it" and I was fed up with her. She had done an lp that showed my spinal fluid b12 was fine, (with the range all things being relative I suppose) but the protein was out of range and she told me my lp was NORMAL.

Any way, sick with nuero problems escalating and only started the b12 this very year.
goofy brained today, went to doc for gait rite test, it's actually on this friday.
more and more mistakes like that every day.

thank you all for listening,
I appreciate any clues you can give me.
laura

Properly packaged SAMe does not need to be kept in the fridge.
It should be blisterpacked to exclude moisture.

SAMe does not dissolve in the stomach. If you do not take it with enough
water, it could conceivably sit like a "pit" in your stomach and cause a local
reaction. This can happen from any dosage form for any drug that is not
properly swallowed with adequate water. At least 4oz, but preferably 6-8.

hello,
the sam-e I got from the health food store,
cost $40 and is made by Jarrow Formulas
"Natural SAM-e full potency 400 elemental sam-e
hightest concentration of active S,S Form"
blister packed and sold out of the fridge where I keep it.

Is this good?
Or did I waste my moolah?

thanks,
laura

lahgarden (hey,it's clever of you to not capitalize your name-easier to type!!)

Anyway, I'm wondering about the dosage of B12 you are getting. My little pink pills are 1 MG.

Maybe someone can explain what all the dosage letters mean?

Also, have you considered dropping the SAMe stuff & see if it helps your tummy?

Here's some more whacky brain incidents I've had: went an entire year thinking (insisting actually), that I was a year older than I was.

Would get in shower & wonder how to turn it on,also would forget to shampoo hair & have to get back in.

Gave my maiden name over the phone (which I hadn't used in over 34 years)

Used a combination of my parent's phone number & my own.

Wrote my own address down rather than the person I was mailing a letter to.

Did I think I had early dementia?? You bet ya! Since I'd been told possible Parkinson's I suppose I just figured I was odd enough to have BOTH mental & physical problems from it (my research had shown you either present with one or the other,seldom both).

Hope some of my brain quirks gave someone a chuckle The point is that B vits have saved my life!

Take care & don't despair! Buttons

You made me laugh,
and not at your expense I assure you.

Just this afternoon I was surprised to learn I was a year younger than I thought!!!!

I'm surprised I'm still employed considering the idiotic mistakes I make all the time.

I have picked up a sort of dyslexia, I write numbers all wrong..........so when you route a truck to make a plant delivery, it can kinda get pretty ugly.

I mix up different genus' of plants.......I just shipped a boat load of the wrong plants last week, cause my dingy brain heard what it wanted.

I even speak entire sentences BACKWARDS. Even though they were small sentences, it is freaky...word for word.
Sometimes I slur my words so badly I bite big chunks out of my tongue.

I am constantly using the wrong word for things, and it's like an echo chamber cause people say them back to me........."moustache? do you mean magazine?"..........."hopscotch? do you mean horseback?"
it's so goofy.

I definately forget how to turn on the shower too!

Last week at work I was very diligently reloading my stapler with PAPER CLIPS.

Alzheimers got my paternal grandmother, and my mother's brother may have it too......it's a scary thing to contemplate. I wouldn't even go there if I were you......way too scary.........this b12/ms/mito business is scary enough!!

I get a shot of 1000mcg's a week of B12.
and thanks to all of you, I got out my vitamins and I'm getting back to task with them.

I'm trying like crazy not to despair.
some days I can cope just fine......
I'm grateful for the encouragement.
laura