Keeping a Time Line - i.e. notes

rose · 08-12-2007, 01:33 PM

Of course, symptoms vary, and of course many being damaged by B12 deficiency are not anemic. That is what I have saying for years. That is why I have been bothering to do this. I don't what that was in response to.

Memory, other psychiatric problems, severe motor problems (and often resulting imbalance), etc. are central nervous system problems.

Pernicious anemia is not a form of B12 deficiency. Pernicious anemia is the inability to secrete intrinsic factor. Pernicious anemia has been known for many years now to be the primary cause of severe B12 malabsorption. If someone take lots of B12 and has been deficient for years, they will almost surely still lack intrinsic factor; thus, they still have "pernicious anemia."

Normal nerve function is necessary for normal muscle function.

rose

ConsiderThis · 08-12-2007, 02:03 PM

Pernicious anemia, which my mother had, has been described in some recent research as an advanced form of B12 deficiency.

Quote:

Originally Posted by Research excerpt quoted on Karen Kline's web site

"Pernicious anemia results from a deficiency of cobalamin, or vitamin B12. The neurological symptoms
associated with cobalamin deficiency were identified more than 100 years ago. Today, cobalamin deficiency is more likely to be recognized in its earlier stages, and the associated neurological symptoms are more easily reversed by vitamin B12 treatment." Neurologic aspects of cobalamin deficiency, Medicine, July 1991, research by: Heaton, Savage, Brust, Garrett, Lindenbaum.

Quote:

Originally Posted by research excerpt quoted on Karen Kline's web site

"Classical disorders such as pernicious anemia are the cause of this deficiency in only a small proportion of the elderly. A more frequent problem is food-cobalamin malabsorption which usually arises from atrophic gastritis and hypochlorhydria but other mechanisms seem to be involved in some patients." Cobalamin, the stomach, and ageing. American Journal of Clinial Nutrition. Oct. 1997.

Quote:

Originally Posted by research excerpt quoted on Karen Kline's web site

"The partial nature of this form of malabsorption produces a more slowly progressive depletion of cobalamin than does the more complete malabsorption engendered by disruption of intrinsic factor-mediated absorption. The slower progression of depletion probably explains why mild, preclinical deficiency is associated with food-cobalamin malabsorption more often than with pernicious anemia." Cobalamin, the stomach, and ageing. American Journal of Clinial Nutrition. Oct. 1997.

Quote:

Originally Posted by Research excerpt quoted on Karen Kline's web site

"It has been proposed that pernicious anemia may represent the final phase of a process that begins with H pylori--associated gastritis and evolves through progressive levels of atrophy until parietal cell mass is entirely lost." Helicobacter pylori--Is It a Novel Causative Agent in Vitamin [B.sub.12]
Deficiency? Archives of Internal Medicine. May 2000.

Quote:

Originally Posted by Research excerpt quoted on Karen Kline's web site

"In a retrospective study that was conducted in 1994 and 1995, we demonstrated that a majority (55%) of cases of cyanocobalamin (vitamin [B.sub.12]) deficiency were related to the inability to release cobalamin from food and that pernicious anemia was a rare condition (17%). In a second retrospective study that was conducted between 1995 and 1998, we confirmed that food cobalamin malabsorption was emerging as a major cause of vitamin [B.sub.12] deficiency. We found that 68 patients (60%) had a vitamin [B.sub.12] deficiency caused by food cobalamin malabsorption and 7 subjects (6%) had pernicious anemia." Food Cobalamin Malabsorption: A Usual Cause of Vitamin [B.sub.12] Deficiency. Archives of Internal Medicine. July 2000.

Please notice how not everyone in a study has exactly the same results, and the different results are reported.

There are more that I could quote.... but this shows the general idea.

Rose wrote-

Quote:

Originally Posted by rose

Of course, symptoms vary, and of course many being damaged by B12 deficiency are not anemic. That is what I have saying for years. That is why I have been bothering to do this. I don't what that was in response to.

Memory, other psychiatric problems, severe motor problems (and often resulting imbalance), etc. are central nervous system problems.

Pernicious anemia is not a form of B12 deficiency. Pernicious anemia is the inability to secrete intrinsic factor. Pernicious anemia has been known for many years now to be the primary cause of severe B12 malabsorption. If someone take lots of B12 and has been deficient for years, they will almost surely still lack intrinsic factor; thus, they still have "pernicious anemia."

Normal nerve function is necessary for normal muscle function.

rose

kimmydawn · 08-12-2007, 08:58 PM

Several posts at the end of this thread have been removed.

Some may come back, but I'm letting readers know, and I'm sorry for any confusion.

KD

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