Selenium causing peipheral neuropathy?

mrsD · 06-02-2008, 04:08 PM

http://lpi.oregonstate.edu/infocente...ium/index.html

Quote:

Toxicity

Although selenium is required for health, like other nutrients, high doses of selenium can be toxic. Acute and fatal toxicities have occurred with accidental or suicidal ingestion of gram quantities of selenium. Clinically significant selenium toxicity was reported in 13 individuals after taking supplements that contained 27.3 milligrams (27,300 mcg) per tablet due to a manufacturing error. Chronic selenium toxicity (selenosis) may occur with smaller doses of selenium over long periods of time. The most frequently reported symptoms of selenosis are hair and nail brittleness and loss. Other symptoms may include gastrointestinal disturbances, skin rashes, a garlic breath odor, fatigue, irritability, and nervous system abnormalities. In an area of China with a high prevalence of selenosis, toxic effects occurred with increasing frequency when blood selenium concentrations reached a level corresponding to an intake of 850 mcg/day. The Food and Nutrition Board (FNB) of the Institute of Medicine recently set the tolerable upper intake level (UL) for selenium at 400 mcg/day in adults based on the prevention of hair and nail brittleness and loss and early signs of chronic selenium toxicity (15). The UL of 400 mcg/day for adults (see table below) includes selenium obtained from food, which averages about 100 mcg/day for adults in the U.S., as well as selenium from supplements. For more information on the data used to set the recent RDA and UL for selenium, see The New Recommendations for Dietary Antioxidants: A Response and Position Statement by the Linus Pauling Institute in the Spring/Summer 2000 issue of the Linus Pauling Institute newsletter.

The only negative thing I have seen recently is this:

Quote:

Only a few studies have examined whether selenium status influences risk for type 2 diabetes mellitus and results are conflicting. One study found that lower toenail selenium levels in men with type 2 diabetes than in non-diabetic men (47); in contrast, another study reported higher serum selenium levels in type 2 diabetics (48). A recent randomized, double-blind, placebo-controlled study in 1,202 men and women participating in the Nutritional Prevention of Cancer trial found that selenium supplementation (200 mcg/day; mean follow-up of 7.7 years) was linked to an increase in prevalence of type 2 diabetes (49).

from the same source material.

Given that diabetes is a major cause of PN.... the two might be linked for you.
Or not.... it is hard to say at this time.

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