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ALS News & Research For postings of news or research links and articles related to ALS |
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12-31-2007, 02:35 PM | #1 | ||
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Hello Peoples*)*!)!!
It won't let me post the ALS Lyme page link so I can't. I will post it in 10 posts*)! Because I am new again here, but I was here for years years ago. There is a IV Rocepihn trial right now where you can get ONE YEAR of IV Rocephin free or placebo unfortunately- I used to be here years back in the Lyme section- I'm Sarah O aka CaliforniaLyme. I was a neuro mutt, now 100% symptom free, thanks to 9 months of IV Rocepihn. I was, looking back, more Parkie than anything else- I had chorea with athetosis and progressive weakness and choking and bradykinesia and lots of yucky stuff- FMS CFS MCS- If you are in SANTA CRUZ COUNTY CA that is the #1 place for Lyme disease in CA just fyi- Take care- Sarah O The acamprosate abstract is this- it could possibly help people with TBE virus induced ALS- or plain ALS because it is a furin inhibitor!!!! ANYWAY- it's cheap- it won't hurt- and it COULD HELP! Consideration of acamprosate for treatment of ALS 1: Med Hypotheses. 2007;69(4):836-7. Epub 2007 Mar 21. Consideration of acamprosate for treatment of amyotrophic lateral sclerosis. Kast RE, Altschuler EL. Department of Psychiatry, University of Vermont, College of Medicine, 2 Church Street, Burlington, VT 05401, USA. rekast@email.com Amyotrophic lateral sclerosis (ALS) is a fatal disease of degeneration of motor neurons. There is no known cure or life extending treatment. Much recent work has suggested that a possible cause of ALS is constitutive opening of the calcium pore in glutamate sensitive AMPA channels secondary to a failure of RNA editing that would change a crucial glutamate in the channel to arginine. Here, we point out that the small molecule pharmaceutical acamprosate, usually used as a drug to maintain alcohol abstinence, may block this calcium pore--as do the related molecules endogenous polyamines such as putrescine, cadaverine, spermidine and spermine--and thus might have use in ALS. PMID: 17368956 |
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