[Mari]

Originally Posted by waves

hen lifting wiriting from elsewhere, if you would identify

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743356/

Indian J Endocrinol Metab. 2013 Jul-Aug; 17(4): 580–587.
Impact of alcohol use on thyroid function

[bizi]

thank you waves for your valuable input. I can always count on you to help me get the numbers straight or research. thank you , I mean that.
my triglycerides are 62 which is very good. My HDL has always been high usually over 100 but never this high.
my tsh was 2.6 last year. t3- was 30, free t4 was 1.07, t-4 6.6.
I will retest next year too not now as I have been drinking quite a bit. so will take it easy with the drinking over the next month.
biz
thanks mari for bringing up the site, your are so smart I don't even know how you did that! I know better to quote things just really flustered.

[bizi]

my pdoc reccomended that I see an endocrinologist.
I am thinking about getting a new gp.
my pdoc also wanted to double my lamictal from 200mg once a day to 200mg twice a day. I told her that I thought that lamictal was generally good more for its anti depressant qualities. She wants me to stop drinking. I told her that I would cut back and let her know how things went after the holidays. Then she said we could then consider adding a small dose of lamictal if we need to.
what do you guys think about increasing lamictal for elevated mood?
bizi

[Mari]

Originally Posted by bizi

thanks mari for bringing up the site, your are so smart I don't even know how you did that!

Bizi,

Everything is o.k.

Mari

[Mari]

Originally Posted by bizi

what do you guys think about increasing lamictal for elevated mood?
bizi

Bizi,

Re Lamictal:

1. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis
http://www.sciencedirect.com/science...40673611608738

This study showed that Lamictal was no better than placebo for acute mania:
whereas gabapentin, lamotrigine, and topiramate were not . . . .

2. http://jop.sagepub.com/content/25/10/1289.short
Lamotrigine: when and where does it act in affective disorders? A systematic review

There was no evidence of effectiveness in the acute treatment of mania, mixed episodes, unipolar depression or rapid-cycling bipolar I disorder.
Its effect in the acute treatment of bipolar depression is at most small.

I am taking three meds that are not supposed to work:
Verapamil
Lamictal
Gabapentin

It seems to be trial and error with drugs --either known to be effective or not.
Besides, you do do not have "acute" mania. You have some degree of mood elevation that I would not be able to define,
but you probably are aware if you want to lower your mood a little.

M

[bizi]

I got myself into trouble today.
I forgot to take my noon geodon. by 6;30pm I was a mess and did not realise that I had forgotten to take it till i was shaking and asked myself"what is wrong with me" it was like having a major hypoglycemic attack.....that is when it dawned on me.
sigh
We went to the concert and I came home and ate 500 calories of fat and took a geodon. Now am just waiting to feel better.
bizi

[bizi]

The unexpected finding of high HDL cholesterol in patients not taking lipid-lowering drugs should prompt a diagnostic evaluation for a secondary cause with measurements of AST, ALT, and thyroid-stimulating hormone; a negative evaluation suggests a possible primary cause.

waves, are the ast alt liver function tests? and what is the thyroid stimulating hormone>?
thanks bizi

[Mari]

Originally Posted by bizi

waves, are the ast alt liver function tests? and what is the thyroid stimulating hormone>?
thanks bizi

Liver function tests: ALT and AST
http://www.webmd.boots.com/a-to-z-gu...function-tests

Thyroid-Stimulating Hormone (TSH)
http://www.webmd.com/women/thyroid-s...ng-hormone-tsh


M

[Mari]

Originally Posted by bizi

I got myself into trouble today.
I forgot to take my noon geodon. by 6;30pm I was a mess and did not realise that I had forgotten to take it till i was shaking and asked myself"what is wrong with me" it was like having a major hypoglycemic attack.....that is when it dawned on me.
sigh
We went to the concert and I came home and ate 500 calories of fat and took a geodon. Now am just waiting to feel better.
bizi

Wow. Good thing that you took care of yourself.

If I miss my Verapamil by a few hours I feel awful.

Mari

[waves]

Originally Posted by bizi

waves, are the ast alt liver function tests? and what is the thyroid stimulating hormone>?
thanks bizi

AST AND ALT are both liver enzymes used to break down nutrients. These are called transaminases because they move the amino ring out of certain amino acids. These are the standard liver function tests. In cases of liver malfunction, excesses of these can end up in the blood.

Isolated excess in the blood of one or the other or specific combinations of enzymes can indicate other types of conditions.

Some meds can cause elevated levels of some of these (and other) liver enzymes. This needs to be taken into account when interpreting lab findings, but high levels must always be monitored, and any offending drugs might need to be removed or reduced.

================

Thyroid stimulating hormone (TSH) is a hormone produced by the pituitary gland. T4 is produced by the thyroid.

Here is a very simplistic explanation of how TSH and T4 are related. TSH is the pituitary's messenger to the thyroid, to stimulate the thyroid to make more T4. The pituitary "sees" what circulating levels of T4 are. If they are too low, the pituitary says, "Hey Thyroid, wake up, work harder!". It says this by making more TSH. If there is too much T4, the pituitary will make less TSH, telling the thyroid to slow down.

With a normally functioning thyroid and pituitary gland, this chemical dialog between them maintains a perpetual equilibrium, where both TSH and T4 remain within "reasonable" levels (expected clinical range).

In the case of a thyroid that is underactive, it can't meet the pituitary's "request" (TSH). So you end up with high TSH, but low T4 (output by thyroid). High TSH + Low T4 = hypothyroidism.

In the case of an overactive thyroid, which puts out too much T4, the pituitary downregulates its own output of TSH. This is like saying to the thyroid, "Hey, you're overdoing it! Slow down!" But the thyroid is manic, can't slow down, and keeps on pumping out T4. So then you have the opposite situation: low TSH + High T4 = hyperthyroidism. -- edited to corrrect


waves