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Old 12-07-2007, 10:38 AM #1
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Question If you don't mind revealing...

What drug was affected for you fibrowendy?
Send me a PM if you don't want to post. I am curious, and will keep it
confidential. (I may be able to help someone else, with this issue in the future).
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Old 12-07-2007, 11:08 AM #2
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I drink grapefruit juice all the time, but I don't see any of my meds on that list.

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Old 12-08-2007, 03:18 AM #3
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I take Verapamil and Klonopin -- both of these are effected by grapefruit juice.

I suspect that they are also effected by other citrus too. But I got a "D" in high school chemistry and can't figure out these studies on my own.
And I can't trust drs to give me good advice either.
Good freaking luck getting a dr who knows anything about food and med reaction.

I like Pomegranate juice. I suspect, in my case, that I can drink a little of it now and then but not regularly.

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Old 12-08-2007, 04:19 AM #4
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Post SOME citrus - but not all

lime
SOUR orange or Seville oranges
possibly bergamot

have similar metabolic effects as does grapefruit, whereas

lemons
sweet orange varieties

appear to be safe.

tangerines and hybrids i don't recall reading about.

also, the effect on meds metabolism appears less related to originally the originally indicted flavonoid, but rather to the action of contained fumarocoumarins(hmm?), also present in smoke, smoked and charred foods (makes ya think about the "bitter" quality of these indicted citrus. These may affect UGT processes (a different enzyme system than the CYP group) as well - aside from the CYP interactions earlier mentioned. However those mechanisms, are, to me, not well understood. i can't recall yet if the article talked about the UGT processes wrt smoking. The effects i do know of regarding smoking pertain to the CYP interactions i.e. 1A2 increases olanzapine clearance but now i'm rambling waaaaaaayy off topic.

most of this stuff is the post-short-term-memory-impaired remnants of an article i read ... will find link for another time am sorry am not up to it.

such a good researcher i am these days. bad waves.
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Old 12-09-2007, 02:46 AM #5
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Quote:
Originally Posted by waves View Post
lime
SOUR orange or Seville oranges
possibly bergamot

have similar metabolic effects as does grapefruit, whereas

lemons
sweet orange varieties

appear to be safe.

tangerines and hybrids i don't recall reading about.
Dear Waves,
Thanks for answering the citrus question again.
I forget it because I like limes much better than lemons.

That's ok. I can learn to like lemon juice.

I imagine that one day I will not need the meds and will not need to take food and other various precautions. I will be all better. I keep telling myself that.

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Old 12-10-2007, 01:47 PM #6
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Here is a list of the meds that I took that were affected. Buspar, depakote and dalmane. All my stabilizers. I was a nervous, aggitated wreck for days and still my body isn't back to where it should. I'm not eating right. Lunch is a toss up lately...don't feel like eating.
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Old 12-10-2007, 05:01 PM #7
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Lightbulb Depakote is hard on some people...

Just by itself.
Here is a monograph:
http://www.drugdigest.org/DD/DVH/Use...psules,00.html

Does your doctor test your liver regularly?
Depakote can screw up liver functions in some people.

Also with time Depakote can lower carnitine levels in the body. So you can
ask for a carnitine test. In some people this can become extreme, and deaths have occurred.
http://findarticles.com/p/articles/m...0/ai_n15855244

http://professionals.epilepsy.com/me...eriouside.html
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