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bizi 05-23-2008 11:10 PM

In regards to restless leg syndrome....
 
Klonopin/ Rivotril (Clonazepam)

Klonopin comes in 0.5 mg, 1 mg, and 2 mg tablets. The usual dose range is 0.5 to 2 mg. This was the first drug used for RLS and PLMD. This is due to its previous use in myoclonic seizures. PLMD used to be called nocturnal myoclonus and thus this drug was tried for RLS/PLMD with great success.
The drug has a rapid onset of action (less than 30 min) but it has a very long half-life (30-40 hours) causing a duration of action of 8-12 hours or longer. Daytime sleepiness can be a problem in a large percentage of patients on Klonopin. We therefore do not recommend this drug for most patients with RLS. It is, however, very commonly prescribed for RLS due to its early association with the treatment of RLS. It may work well in patients who do have morning RLS and do not get drowsy or sleepy due to the long lasting nature of this drug (which may persist at high levels in the morning causing daytime sleepiness).
Many physicians prescribe Klonopin, as this is the original drug used for RLS and is recommended by all the general medical textbooks that discuss RLS. Some sleep specialists (and patients) prefer to use this drug for RLS, but our experience has been that the shorter acting sedatives work better for most RLS sufferers.



that is a long half life!
Just thought I would post this for you mari.
bizi

bizi 05-24-2008 11:32 AM

hubby was sick yesterday so I did not want to disturb him last night so I slept in the other bedroom...just in case it would be another sleepless night of tossing and turning.
Fortunately I slept well.:)
I can deal with this detox if I can continue this not sleeping a few nights and then getting a good nights rest.
I am feeling really good about this....I have high hopes that I will be able to stay off the ambien.

bizi
just wanted to add, it has been one week off the ambien!

bizi 05-24-2008 12:00 PM

From wikepedia....
 
Quote:

Akathisia, or acathisia, is a syndrome characterized by unpleasant sensations of "inner" restlessness that manifests itself with an inability to sit still or remain motionless, hence its origin in Ancient Greek α (a), [without, not] + κάθισις (káthisis), [sitting]. Its most common cause is as a side effect of medications, mainly neuroleptic antipsychotics especially the phenothiazines (such as perphenazine and chlorpromazine), thioxanthenes (such as flupenthixol and zuclopenthixol) and butyrophenones (such as haloperidol (Haldol)), piperazines (such as ziprasidone), and rarely, antidepressants. Akathisia can also, to a lesser extent, be caused by Parkinson disease and related syndromes.[1] But all neuroleptic antipsychotic psychotropic drugs cause Parkinsonian like symptoms due to blockage of dopamine receptors in the nigrostriatal pathway of the brain.
Akathisia may range in intensity from a mild sense of disquiet or anxiety (which may be easily overlooked) to a total inability to sit still, accompanied by overwhelming anxiety, malaise, and severe dysphoria (manifesting as an almost indescribable sense of terror and doom). The condition is difficult for the patient to describe and is often misdiagnosed. When misdiagnosis occurs in antipsychotic neuroleptic-induced akathisia, more antipsychotic neuroleptics may be prescribed, potentially worsening the symptoms.[1] High-functioning patients have described the feeling as a sense of inner tension and torment or chemical torture.
The presence and severity of akathisia can be measured using the Barnes Akathisia Scale.[2][3][4]

So the restless leg stuff could be from the geodon....
I will address this next.
bizi

bizi 05-24-2008 12:27 PM

from wikepedia,,,,
 
Treatment
Treatment includes the discontinuation or reduction of dose of the causative agent.
The most common treatment for antipsychotic akathisia is the anticholinergic medication benztropine (Cogentin). But since benztropine is for extrapyramidal side effects such as muscle spasms, muscle stiffness and tremors it is not effective in treating akathisia which is not a true extrapyramidal side effect. Other anticholinergic medications such as diphenhydramine (benadryl) may also be used in the treatment of akathisia.
Akathisia can be reduced by administering other drugs, though effectiveness can vary with more severe cases resistant to most drug treatment. Benzodiazepines like clonazepam (Klonopin) are effective. Some consider the drug of choice for the treatment of akathisia to be beta-blockers such as propranolol (Inderal) or metoprolol. The antihistamine cyproheptadine is also effective, though with shorter effect than beta blockers.
One study showed that vitamin B6 is effective for the treatment of neuroleptic-induced akathisia.[9]

bizi 06-18-2008 10:24 PM

WEll I have been off of ambien a month and am sleeping some good days some bad days.
Am hoping that this settles out soon.
When I am not sleeping I tend to just lay there quietly, resting...and I count....this tends to distract my wondering brain....I usually count to one hundred then start over again.
bizi

bizi 06-18-2008 10:25 PM

Insomnia.....
http://www.goaskalice.columbia.edu/2415.html
Quote:
Dear Alice,

What are the long-term effects of sleep deprivation?



Dear Reader,

If increased demands in your life have forced you to cut back on your ZZZs, welcome to the club. A century ago, when people went to bed and awoke based on the sun's schedule, the average person could expect to get approximately nine hours of sleep a night. By 1975, nightly slumber was down to about seven-and-a-half hours, and today, one-third of Americans get less than six hours of nocturnal snooze-time. Electricity, television, and computers have created a world that's lit and lively 24/7, and many around the world are sacrificing siesta time to take part.

Chronic sleep deprivation (going for extended periods of time with less sleep than your body needs — which for some could be as much as ten hours a night) can cause a variety of physical and psychological problems. At its most basic level, loss of sleep can make people more irritable, less efficient and able to recall events, and more accident-prone. Research on the physical effects of chronic sleep deprivation suggest more serious and significant long-term complications, including:


Diabetes

Research from the University of Chicago Medical Center has shown that sleep deprivation interferes with the body's ability to regulate insulin production and sugar metabolism, potentially increasing the risk of diabetes.


Weakened immune system

People who don't get enough sleep have been found to have changes in their immune response and white blood cell production, which can lead to difficulty in fighting off infections.


Cognitive problems

It is believed that adequate amounts of sleep are essential for storing and maintaining long-term memories. People who are sleep deprived also score less well on cognitive tasks, such as judgment and reaction time. The National Sleep Foundation estimates that as many as 100,000 car accidents a year may be caused by sleep deprivation.


Obesity

Some scientists believe that sleep deprivation decreases the production of leptin, a hormone that makes people feel "full" after eating. Without enough leptin, people continue to crave carbs even after they've eaten — leading to overeating and possible obesity.

When you cut back on nightly napping, it's not just beauty sleep you're losing — sleep buffs both your body and brain.

Alice

Curious 06-18-2008 10:48 PM

Quote:

Originally Posted by bizi (Post 304475)
WEll I have been off of ambien a month and am sleeping some good days some bad days.
Am hoping that this settles out soon.
When I am not sleeping I tend to just lay there quietly, resting...and I count....this tends to distract my wondering brain....I usually count to one hundred then start over again.
bizi


bizi...you sound normal. i doubt anyone sleeps perfect every night. i thinky ou are doing pretty darn good. :hug:

do you like to read? that helps me. sometimes it distracts me from the pain and also sets my brain to have some pretty cool dreams. :D just make sure there is a hunky man as the main character. :wink:

bizi 06-20-2008 09:49 AM

WEll no sleep...tonight was the worst....I could not jsut lay there quietly, kept tossing and turning, afraid that I was keeping hubby awake.
I think that it has only been one month since ambien....i need to just be patient.
I also need to get better bed time behavior...on the computer again for too long too late.
I seriously thought I was going mad last night.
took an extra geodon this morning....
see how the day progresses.
I slept so well the night before....good days bad days.
bizi

mrsD 06-20-2008 11:01 AM

full moon
 
last two nights... I don't sleep well then either.

I got up went on line for an hour or so and went back to
bed.

I do believe in the full moon, and I have a widget on my desktop in fact that shows its phase each day! LOLOL

bizi 06-20-2008 02:39 PM

hi Mrs.D.
I have been taking slow mag at night 128mg of mag cloride.
This is supposed to have muscle relaxant qualtities....
waiting for this benefit....:rolleyes:
full moon, hormonal perimenopausal issues, withdrawl issues,,,,
blah blah blah
bizi


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