Science can't even indicate if there can be brief moments (or even longer or prolonged periods) where the loss of gained activity in the failing hypothalamus during chronic depression can be greater or less than the loss of pleasure activity only due to the glucocorticoids overworking those pleasure neurons? Again, as before, just a simple answer like "yes, science can answer this," or "no, science can't answer this." Again, this question is in regards to the hypothalamus overworking and failing (losing activity and losing activity that it gains) as a result during chronic depression.

no science cant answer this

Does the hypothalamus overwork and lose activity (fail) as a result of it overworking during chronic depression? Again, you don't have to explain anything--just a yes or a no is fine.

Sorry Matt ----its not as simple as yes or no --can't be answered this way.

Some abonormalties of hypothalmus are found in depression.

Like I said yesterday about the CRF hypothesis was seen in 50% of people with depression.

AS far as your 2 ? goes-------- I agree personally I think there is strong evidence suggest a person can feel worse or even more depressed until the stress/cortisol level is contolled

2 more questions (please answer each one):

1.) If it does lose activity, then there will be moments where some of the activity that it gains during chronic major depression is lost (resulting in little gain) and I'm wondering if there are moments where that little gain can be greater or less than the loss of pleasure activity during depression. Or can science not answer this question either. Again, just a "yes, science can answer this question," or "no, science can't answer this question" is fine.

2.) Now for someone who has chronic major depression, can there be brief moments where he/she will feel temporarily worse (more depressed) only just from one or few instances where the glucocorticoids overwork the neurons? Again, this question is only in regards to the glucocorticoids overworking the neurons, nothing else that contributes to depression.

Edit: I think I already asked this question before, but go ahead and answer it anyway with a yes or a no.

I see that you edited your post to "2 ?" meaning that you have answered my 2nd question in my previous post (the 2nd question in my post already after yours). But could you answer that 1st question in that post as well with a "yes, science can answer this," or "no science can't answer this." It's just that I'm having an obsessive thought over this which is why I am asking.

as far as your ? for #1 -- my reply is science cant answer this

In regards to my 1st question in my above post that you just answered, are you absolutely sure that there is no scientific knowledge, methods, or technology, etc. that can answer whether that little gain (gain that is lost in the failing hypothalamus during chronic major depression resulting in that little gain that I mentioned in my 1st question above) if there are brief moments (like a second or more or less) or even longer moments where that little gain is greater or less than the loss of pleasure activity only due to the glucocorticods overworking the neurons? Again, you can just reply with "yes, there is scientific knowledge, methods, and technology, etc. that can answer this," or "no, there is no scientific knowledge, methods, and technology, etc. that can answer this."

Im sorry Matt but ----there is no scientific knowledge, methods, and technology, that can answer this ?---or at least nothing I have found.

Now for someone who has chronic major depression, even if there are moments where he/she feels alright, the glucocorticods are still overworking and killing the neurons even during those moments of feeling alright.

Now even while the glucocorticoids are still overworking the neurons even during moments where a chronically majorly depressed person feels alright, can there be moments where when he/she then feels extremely little depressed (which would then result in the hypothalamus gaining a rate of extremely little activity since the hypothalamus gains activity during depression), that there will be moments (like a second or more or less or even for longer) where this extremely little rate of activity gained by the hypothalamus is less than (or could it even be greater than) the current rate of loss of pleasure activity due to the glucocorticoids overworking the neurons from the very moment that this person felt alright coupled with the fact that this person's hypothalamus is failing and that this extremely little rate of activity gained becomes even less due to the failure of the hypothalamus?

Again, just answer with "yes, science can answer this," or "no, science can't answer this." And also correct me if I'm wrong on all of this.