Hi, there. Thanks for taking the time to read this. I'm desperate for some guidance.

I'm a 40 year old male with what appears to be some sort of acetylcholine dysregulation. I first contracted symptoms 15 years ago which were both constant tachycardia, very severe depression, nonstop panic and a 'revved' feeling which I assumed was adrenaline.

Long story short no psychotropic medications resolved the tachycardia nor any of the mental symptoms. I tried everything until I discovered phosphatidylserine complex (including ethanolamine and choline) addressed nearly all the symptoms: slowed my heart down reasonably, gave me clarity and I was able to go back to work.

Fast forward 10 years later or about 3 weeks ago I came down with a chest infection and took a Z-pac. The third night of use I was overcome by a panic attack and all of my old symptoms returned. The phosphatidyl serine complex no longer slowed down my heart and my panic returned. However, if I do not take it at all during the day things are worse. It just seems like my ACh is completely unregulated right now. Just a guess.

Sorry for the long winded post, but: any idea what could be happening? Autoimmune reaction? Why the weird reaction to a med that worked for > 10 years. I have had severe digestive problems over the years as well as a sensitive immune system. I wish I just had straightforward depression or anxiety.