I used the SIDE of my thigh in order to find more fat and found that worked well. the top side of your thigh has precious little fat and its too easy to nick into the muscle. go over to the side, grab a hand ful of yummy fat and STAB! ta da no more sore legs. I have heard of folks using the inner thigh but i never ever could find enough courage to do it there. EEEK!

I hope its feeling better now.

I stopped using the front of my thighs since I would bleed like crazy, get dents and graying of the skin.
Neuro said use the side where the fat pad is...but I don't do the thighs at all anymore.

Thanks for all the tips. I've been injecting Copaxone for three years and never had this happen. It made me think of what it must feel like to be shot. I think I'll mark that area strictly off limits.

I have also gone to injecting only 5 times a week, that and some weight gain has begun to fill in the dents.

it must have been muscle because if it was a nerve you would have felt it the first couple of seconds.

i'd chalk it up to weird and unusual.
everyone's advice was great.

I too have been injecting myself, in my case with Interferon for Polycythemia Vera. I inject only into the belly and have no pain, not ANY pain (well, a faint sting). However, the INF is giving me very bad neuropathy in my feet. about 10 hours after the shot, three times a week, the blow torch on my toes starts and goes on for hours. Demerol has not been enough to stop it in the moderate dose I consider OK, so I am taking Tylenol, which is a risk because I have Porphyria too. This is awful. Worst misery of my life, I think, but of course we do forget the horrors we went through, like the neurological impairments I had leading up to MS diagnosis. But for sheer pain, this is as
bad as Shingles, and harder to mollify. I am thinking I may not continue.

Muscle for sure, and what Dej said about avoiding injecting the tops of the thighs, oh yes. I hit a muscle there once and never again (because I switched to the sides). I found myself in the same state, leg in severe pain, difficult to walk, lasted several hours. It was dreadful!

I had the exact same problem with the tops of the thighs. The nurse at my neuro's office suggested I use the sides so now I rotate around using both the insides and outsides of the thighs. I also adjusted the depth on the auto-inject so I'm going a tad deeper - that seems to help with the big lumps that used to appear. I wish I could inject in my stomach every day - that's the easiest area...sounds like it's true for other people as well. It's all trial and error really...this summer I will have been on C for 2 yrs...it does get better. I'm really hoping my MRIs look good so I can stay on it - I've been tolerating it very well and I really don't want to mess around with the side effects of the other drugs...Good luck everyone!