Thank you Chemar~Ericka, that is really kind of you. I view CFS, fibromyalgia and lupus as one disease now though. Even when I was first diagnosed and they would "add" a new disease name with each new symptom, I knew deep down that it was just a "progression" of whatever was wrong with me.

Doydie~I think we will be able to show how your conditions are connected.
SallyC~I am with you on that one.

Following is some information from the link SallyC posted in post no. 12. In the post,I was answering the original posters question on the symptoms of PEDD. I am going to take out the links provided and the body of the information from the studies (per rules). If you click on the link that SallyC provided, you can see the information in total,plus the link to the lupus study. This information makes the connection to protease and some of the symptoms of MS (and lupus etc.) Specifically, the dysregulated iron and resulting restless legs syndrome found in MS. Also, I provided a study that shows certain amino acids are found lacking in fibromyalgia. One in particular is phenylalanine, which is where dopamine is derived from. In my next post, I will provide evidence that MS patients also lack phenylalanine.

From the link that SallyC provided in post 12:
"You can literally trace every symptom of every autoimmune disease directly back to missing enzymes in the pancreas. Specifically protease and DNase1. The information that the previous posters provided show that without protease, your body will not be able to break down immune complexes. These immune complexes consist of unbroken down proteins and DNA also due to a lack of protease, since you would not be able to digest dietary proteins. Your immune system targets these protein fragments and DNA and forms "NETS" that become lodged in your organs and tissues. The lack of the pancreatic enzyme DNase1 has been determined to be a "causative" factor of lupus. Here is a picture of these "NETS" in a lupus patients bloodstream. In the last paragraph, the researchers state lupus patients lack the enzyme DNase1. (See Sally's post for link)

So, that would be one symptom of PEDD, immune complexes that become lodged in organs and tissues, causing organ failure and damage. Other symptoms of PEDD would be the same a lupus patient would suffer, since the lack of DNase1 has been determined to be a causitive factor of lupus. Here are some symptoms and scientific findings of lupus: Autonomic nervous system dysfunction, hypothyroidism, restless legs syndrome, arthritis, osteoporosis, spinal cord degeneration, migraines, hypermobility, low adrenal function, chemical sensitivity, low cortisol, anemia, lack of vitamin B12, iron, and magnesium, joint and muscle pain, fatigue, insomnia, depression, neuropathy, swollen glands, low grade fever, high C-reactive protein, rashes, itchiness, vision complications, dry eyes and mouth, increased risk of heart attack and stroke, easy bruising, brain fog, porphyria, mitochrondrial dysfunction, POTS, heat intolerance, and the list goes on. You can trace each of these symptoms directly back to these missing enzymes.

For instance, lupus patients have an increased risk of developing restless legs syndrome. So do fibromyalgia, diabetes, MS, Sjogrens patietns etc. Studies have linked restless legs syndrome to low iron and dopamine. Here is one such study.

Dopamine and Iron in The Pathophysiology of Restless Legs
Syndrome (Rls)
Allen, R. 2004. Sleep Med. 5(4):385-91.



Here is how PEDD would lead to RLS (and anemia) Protease regulate iron absorption in the body. Here is a study that shows this.
Hörl, W.H. 2008. Nephrol. Dial. Transplant. 23(10):3063-3064.

New Insights Into Intestinal Iron Absorption…Du et al. described the novel and exciting finding that the transmembrane serine
protease 6 (TMPRSS6) senses iron deficiency [1].


PEDD would also lead to a lack of dopamine. Protease break down dietary proteins and release essential amino acids. One of the amino acids found lacking in MS, lupus, Fibromyalgia, CFS etc is phenylalanine. Phenylalanine breaks down into tyrosine and tyrosine breaks down into dopamine. The lack of dopamine and iron would then lead to RLS. Here is a study that shows fibromyalgia patients lack phenylalanine.

Altered Amino Acid Homeostasis in Subjects Affected by
Fibromyalgia
Bazzichi, L., L. Palego, G. Giannaccini, A. Rossi, F. De Feo, C. Giacomelli, L. Betti, L. Giusti,
G. Mascia, S. Bombardieri, A. Lucacchini. 2009. Clin Bioche, 42(10-11):1064-70.

wow...
I am sure I don't understand much of what you are saying yet, however....I too have always thought all my symptoms were somehow related to MS.
I have:
low RBC (3.5 million cells/mcL)
low hemogolbin (11.2 g/dl)
low hematocrit (34%)
low ferritin (down to 10 now)
low vit B12 (I have to do weekly injections)
low Vitamin D (up to 30 now...with daily 3200iu)
Complex partial seizures
Severe Chronic Migraines
Irriatable bowel syndrome
Burning mouth syndrome
and the regular MS symptoms:
fatigue
leg pain, tingling, spasms, spasticity
arm pain with deep burning and aching
bladder retention (I must self-cath)
visual issues
Balance/Coordination problems
depression

I am wanting to know HOW to change all this??

Hello Annesse,

Thank you for the time and effort that you have no doubt put into researching this; and also for sharing it with us.

So far I follow the theory and if what has been suggested turns out to have consistent results with respect to symptom control, that would certainly be quite wonderful; for at that point there is at least one more thing that may be tried and prove to be beneficial with respect to symptom control.

Classifying PEDD as a cause (the seed) and the protocol as a cure, may be a little shaky though (at least from a scientifically definitive standpoint); because it seems that one would need to maintain the protocol (if it did in fact prove to be beneficial), in order to keep symptoms from returning.
That qualifies the protocol as a symptom controlling treatment (much like a medication protocol would), rather than a cure; further supporting the suggestion that the protocol targets a condition (PED), rather than a cause.
In this case a cause would be more akin to the 'factor' that leads to the development or presence of PED.

No matter...it is a bit of a matter of semantics at this point. My interest in defining PED, PEDD correctly with respect to cause, condition or effect has more to do with my own personal interest in analyzing how each of those should be approached and how they would play out with respect to interferences placed upon them: ie. potential treatment methods and protocols.

Before going down that road with respect to PEDD however, it would be helpful to review current differential assessments of the impact of PED within the general population.
Do you know if there have been any studies specifically on PED in the general population?
What I have been looking for in the literature and links, but have yet to find is any study that has examined the disease rate (percentage) of individuals who have PED in the general population.

In other words, has some research evidence revealed through scientific standard testing (greater than 500 general population participants, studied over time), that a certain percentage of, or all individuals who have PED, either have symptoms of, or who go on to develop auto-immune inflammatory type disease such as MS, Lupus etc, or any other specific or predictable disease process as a result?

Such a study would show that either there is a greater, lesser or equal incidence of disease affecting those with PED when compared to disease incidence of the general population.

If you know of something along this line of research, please provide a 'Research paper or Journal title reference' that can be searched on Google or ordered from the publisher.

This is so interesting!

Thanks.

With love, Erika

Sometimes Erika, As in Meds like LDN, although there are some pro scientific studies, "The Proof is In The Pudding"

Isn't that the truth.

With love, Erika

Hi daisy.girl~ I think all of the conditions you listed are connected. We will be able to show how they can all be traced directly back to these missing enzymes.

If you have any questions as we proceed, please don't hesitate to ask. All I am really doing is showing how the symptoms and associated conditions of MS can be traced directly back to these enzymes. I started by addressing the dysregulated iron and RLS found in MS. Protease regulate iron absorption and the lack of iron and dopamine would lead to RLS. Dopamine is derived from phenylalanine. Phenylalanine is an essential amino acid that is derived from high protein foods. That is what protease do, they break down high protein foods and release essential amino acids. I posted a study that shows phenylalanine is lacking in fibromyalgia patients. More than 33% of fibromyalgia patients also have RLS.

MS patients also lack phenylalanine and numerous other amino acids found in high protein foods. The following study found that MS patients lack phenylalanine, tryptophan, leucine, isoleucine, valine, and tyrosine.

Plasma and Cerebrospinal Fluid Tryptophan in Multiple Sclerosis
and Degenerative Diseases
Monaco, F., S. Fumero, A. Mondino, R. Mutani. 1979. J. Neurol. Neurosurg. Psychiatry
42:640-641.

The lack of phenylalanine would not only lead to RLS (due to a lack of dopamine) it would also explain many of the other symptoms found in MS. Here is a list of the known symptoms of dopamine deficiency.

• Stiff, rigid, achy muscles
• Cognitive impairment
• Impaired motor skills
• Tremors
• Inability to focus attention
• Poor balance and coordination
• Strange walking pattern (gait), frequently with small steps

Hey Erika~As far as I know, I was the first person to use the term "PEDD" so there wouldn't have been any studies done.

Following is a quote from an article in US News & World Report
(University of Illinois at Chicago, 2011).

*edit due to copyright* The study was published
online February 4, 2011 in Brain.

This is additional evidence of the lack of phenylalanine, tyrosine and dopamine in MS. Adrenaline and noradrenaline are derived from dopamine.

So, just to recap;Protease (pancreatic enzymes) break down high protein foods and release essential amino acids. Phenylalanine and tyrosine are two essential amino acids derived from "high protein foods" that are found lacking in MS. Phenylalanine breaks down into tyrosine, tyrosine breaks down into dopamine and dopamine breaks down into adrenaline and noradrenaline.

We are not done with phenylalanine just yet. In the next post, I'll show how a lack of phenylalanine would explain two other conditions found in MS.

Another reminder about please not directly copy/pasting from *any* site or publication that has a copyright notice.

Thanks Annesse,

QUOTE: "Phenylalanine breaks down into tyrosine, tyrosine breaks down into dopamine and dopamine breaks down into adrenaline and noradrenaline."

I'd like to correct a slight error in terminology so as to avoid possible confusion and more importantly, the potential for health effects should anyone choose to supplement any of these amino acids (some are available in isolated form in health food stores).

Phenylalanine is a 'precursor' to tyrosine which in turn is a precursor to dopamine, as well as a component of other neurotransmitters.

NOTE: Supplementing amino acids in isolation is a form of nutritional pharmacology and as with other pharmacological approaches, it is advisable to research 'uses, side effects, contra-indications, interactions with other medications and the potential health risks' before doing so.
There is ample information on the internet with respect to each amino acid along with these factors as well as providing descriptions with respect to their effects on body functions.

With love, Erika

why all the bits and pieces??

just say it all in one post please!